FtsZ-IN-7 

FtsZ-IN-7 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-7 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-7 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-7 shows low hemolytic activity and cytotoxicity to mammalian cells^[1].

FtsZ-IN-7 (compound B8) inhibits the tested Gram-positive bacteria including methicillin-resistant S. aureus (MRSA) (MIC=0.049 μg/mL), B. subtilis (MIC=0.024 μg/mL) and S. pneumoniae (MIC=0.049 μg/mL)^[1].
FtsZ-IN-7 (1-4× MIC; 0-24 h) inhibits bacterial grwoth. And FtsZ-IN-7 (4× MIC; 4 h) disturbs the cell surface of MRSA ATCC43300, with notable wrinkling and filamentation on their surfaces^[1].
FtsZ-IN-7 (4 μg/mL; 10 min; 25 ℃) promotes FtsZ polymerization and (0.02-0.64 μg/mL; 30 min) inhibits the GTPase activity of FtsZ dose-dependently^[1].
FtsZ-IN-7 (12.5 μg/mL; 1 h; 37 ℃) revealing the negligible hemolytic activity against human erythrocytes RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

500.34

C₂₆H₁₈BrN₃O₃

COC1=C(C=CC=C1)NC(C2=CC3=C(NC4=C3C=C[N+]5=C4C(C6=C5C=CC=C6)=O)C=C2)=O.[Br-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Qiu H, et al. Design and synthesis of fascaplysin derivatives as inhibitors of FtsZ with potent antibacterial activity and mechanistic study. Eur J Med Chem. 2023 Jun 5;254:115348.  [Content Brief]