2. Apoptosis
  3. c-Myc
  4. FUBP1-IN-2

FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines.

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FUBP1-IN-2 Chemical Structure

FUBP1-IN-2 Chemical Structure

CAS No. : 1242862-71-0

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FUBP1-IN-2 Related Antibodies

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Description

FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].

Cellular Effect
Cell Line Type Value Description References
CHO-K1 EC50
> 40 μM
Compound: 9; 0754479
Inhibition of spermidine uptake chinese hamster CHO-K1 cells assessed as decrease in cell growth by measuring cellular ATP content measured after 48 hrs in presence of DFMO and spermidine by ATPlite assay
Inhibition of spermidine uptake chinese hamster CHO-K1 cells assessed as decrease in cell growth by measuring cellular ATP content measured after 48 hrs in presence of DFMO and spermidine by ATPlite assay
[PMID: 36382923]
CHO-K1 EC50
8 μM
Compound: 9; 0754479
Inhibition of polyamine uptake in chinese hamster CHO-K1 cells assessed as rescue of Ant44-induced toxicity by measuring cellular ATP content measured after 48 hrs in presence of Ant44 and aminoguanidine by ATPlite assay
Inhibition of polyamine uptake in chinese hamster CHO-K1 cells assessed as rescue of Ant44-induced toxicity by measuring cellular ATP content measured after 48 hrs in presence of Ant44 and aminoguanidine by ATPlite assay
[PMID: 36382923]
L3.6pl IC50
16.8 μM
Compound: 9; 0754479
Cytotoxicity against human L3.6pl cells cells assessed as inhibition of cell growth measured after 72 hrs by ATPlite assay
Cytotoxicity against human L3.6pl cells cells assessed as inhibition of cell growth measured after 72 hrs by ATPlite assay
[PMID: 36382923]
In Vitro

FUBP1-IN-2 (compound 9) does not inhibit 3 H-spermidine uptake yet works synergistically with Eflornithine (HY-B0744) to limit cell growth in the presence of exogenous spermidine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FUBP1-IN-2 Related Antibodies
Molecular Weight

479.96

Formula

C26H26ClN3O4
CAS No.
SMILES

COC1=CC=C(C=C1)C(NC2=C(C=C(C=C2)N3CCN(CC3)C4=C(C=CC(Cl)=C4)C)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FUBP1-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FUBP1-IN-21242862-71-0c-MycMycCHO-K1 cellsFUBP1far upstream binding protein 1FUBP1-FUSEp21polyaminesInhibitorinhibitorinhibit

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