2. Others Vitamin D Related/Nuclear Receptor Autophagy Apoptosis
  3. Isotope-Labeled Compounds Estrogen Receptor/ERR Autophagy Apoptosis
  4. Fulvestrant-d3

Fulvestrant-d3  (Synonyms: ICI 182780-d3; ZD 9238-d3; ZM 182780-d3)

Cat. No.: HY-13636S Purity: 97.47%
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Fulvestrant-d3 is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].

For research use only. We do not sell to patients.

Fulvestrant-d<sub>3</sub> Chemical Structure

Fulvestrant-d3 Chemical Structure

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500 μg USD 335 In-stock
1 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Fulvestrant-d3:

Fulvestrant-d3 Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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  • Purity & Documentation

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Description

Fulvestrant-d3 is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fulvestrant-d3 Related Antibodies
Molecular Weight

609.79

Formula

C32H44D3F5O3S
Unlabeled CAS

129453-61-8
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](O)([2H])C([2H])([2H])C[C@@]1([H])[C@]3([H])[C@H](CCCCCCCCCS(CCCC(F)(F)C(F)(F)F)=O)CC4=C(C=CC(O)=C4)[C@@]3([H])CC2
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (409.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6399 mL 8.1995 mL 16.3991 mL
5 mM 0.3280 mL 1.6399 mL 3.2798 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6399 mL 8.1995 mL 16.3991 mL 40.9977 mL
5 mM 0.3280 mL 1.6399 mL 3.2798 mL 8.1995 mL
10 mM 0.1640 mL 0.8200 mL 1.6399 mL 4.0998 mL
15 mM 0.1093 mL 0.5466 mL 1.0933 mL 2.7332 mL
20 mM 0.0820 mL 0.4100 mL 0.8200 mL 2.0499 mL
25 mM 0.0656 mL 0.3280 mL 0.6560 mL 1.6399 mL
30 mM 0.0547 mL 0.2733 mL 0.5466 mL 1.3666 mL
40 mM 0.0410 mL 0.2050 mL 0.4100 mL 1.0249 mL
50 mM 0.0328 mL 0.1640 mL 0.3280 mL 0.8200 mL
60 mM 0.0273 mL 0.1367 mL 0.2733 mL 0.6833 mL
80 mM 0.0205 mL 0.1025 mL 0.2050 mL 0.5125 mL
100 mM 0.0164 mL 0.0820 mL 0.1640 mL 0.4100 mL
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Fulvestrant-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fulvestrant-d3ICI 182780-d3ZD 9238-d3ZM 182780-d3Isotope-Labeled CompoundsEstrogen Receptor/ERRAutophagyApoptosisInhibitorinhibitorinhibit

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