2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. NKCC GABA Receptor
  4. Furosemide-d5

Furosemide-d5 is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

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Furosemide-d<sub>5</sub> Chemical Structure

Furosemide-d5 Chemical Structure

CAS No. : 1189482-35-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Furosemide-d5:

Furosemide-d5 Related Antibodies

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Description

Furosemide-d5 is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Furosemide-d5 Related Antibodies
Molecular Weight

335.77

Formula

C12H6D5ClN2O5S
CAS No.
Unlabeled CAS

54-31-9
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=C(C=C(C(S(N)(=O)=O)=C1)Cl)NC([2H])([2H])C2=C([2H])C([2H])=C([2H])O2)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (297.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 100 mg/mL (297.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9782 mL 14.8911 mL 29.7823 mL
5 mM 0.5956 mL 2.9782 mL 5.9565 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.9782 mL 14.8911 mL 29.7823 mL 74.4557 mL
5 mM 0.5956 mL 2.9782 mL 5.9565 mL 14.8911 mL
10 mM 0.2978 mL 1.4891 mL 2.9782 mL 7.4456 mL
15 mM 0.1985 mL 0.9927 mL 1.9855 mL 4.9637 mL
20 mM 0.1489 mL 0.7446 mL 1.4891 mL 3.7228 mL
25 mM 0.1191 mL 0.5956 mL 1.1913 mL 2.9782 mL
30 mM 0.0993 mL 0.4964 mL 0.9927 mL 2.4819 mL
40 mM 0.0745 mL 0.3723 mL 0.7446 mL 1.8614 mL
50 mM 0.0596 mL 0.2978 mL 0.5956 mL 1.4891 mL
60 mM 0.0496 mL 0.2482 mL 0.4964 mL 1.2409 mL
80 mM 0.0372 mL 0.1861 mL 0.3723 mL 0.9307 mL
100 mM 0.0298 mL 0.1489 mL 0.2978 mL 0.7446 mL
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Furosemide-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Furosemide-d51189482-35-6NKCCGABA ReceptorNa-K-Cl cotransporterNa(+)-K(+)-Cl(-) cotransporterNa+-K+-Cl− cotransporter Gamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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