2. Anti-infection
  3. SARS-CoV
  4. FWM-1

FWM-1 is a potent SARS-COV-2 NSP13 helicase enzyme inhibitor with binding free energy equals -328.6 kcal/mol. FWM-1 effectively disrupts the binding of ATP to the SARS-COV2 helicase enzyme.

For research use only. We do not sell to patients.

FWM-1 Chemical Structure

FWM-1 Chemical Structure

Size Price Stock Quantity
5 mg USD 190 In-stock
10 mg USD 300 In-stock
25 mg USD 600 In-stock
50 mg USD 960 In-stock
100 mg USD 1530 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

FWM-1 Related Antibodies

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Description

FWM-1 is a potent SARS-COV-2 NSP13 helicase enzyme inhibitor with binding free energy equals -328.6 kcal/mol. FWM-1 effectively disrupts the binding of ATP to the SARS-COV2 helicase enzyme[1].

IC50 & Target

NSP13[1].
Molecular Weight

410.86

Formula

C15H11ClN4O4S2
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(NC(O)=C1C(C2=C(NC(NC2=O)=S)O)C3=CC=C(C=C3)Cl)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (121.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4339 mL 12.1696 mL 24.3392 mL
5 mM 0.4868 mL 2.4339 mL 4.8678 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4339 mL 12.1696 mL 24.3392 mL 60.8480 mL
5 mM 0.4868 mL 2.4339 mL 4.8678 mL 12.1696 mL
10 mM 0.2434 mL 1.2170 mL 2.4339 mL 6.0848 mL
15 mM 0.1623 mL 0.8113 mL 1.6226 mL 4.0565 mL
20 mM 0.1217 mL 0.6085 mL 1.2170 mL 3.0424 mL
25 mM 0.0974 mL 0.4868 mL 0.9736 mL 2.4339 mL
30 mM 0.0811 mL 0.4057 mL 0.8113 mL 2.0283 mL
40 mM 0.0608 mL 0.3042 mL 0.6085 mL 1.5212 mL
50 mM 0.0487 mL 0.2434 mL 0.4868 mL 1.2170 mL
60 mM 0.0406 mL 0.2028 mL 0.4057 mL 1.0141 mL
80 mM 0.0304 mL 0.1521 mL 0.3042 mL 0.7606 mL
100 mM 0.0243 mL 0.1217 mL 0.2434 mL 0.6085 mL
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FWM-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FWM-1FWM1FWM 1SARS-CoVSARS coronavirusSARS-COV-2structure-based pharmacophoreATPInhibitorinhibitorinhibit

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