2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Gü1303

Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen.

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Gü1303 Chemical Structure

Gü1303 Chemical Structure

CAS No. : 1043922-53-7

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Gü1303 Related Antibodies

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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Description

Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

IC50 & Target

Ki: 0.91 nM (mCatK)[1]
Cellular Effect
Cell Line Type Value Description References
LLC-MK2 CC50
42 μM
Compound: Neq0677
Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34095840]
U2OS CC50
10.2 μM
Compound: Neq0677
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34095840]
Molecular Weight

366.41

Formula

C20H22N4O3
CAS No.
SMILES

CN(N(C([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)C)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gü1303 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gü13031043922-53-7Cathepsincathepsin Kprotease inhibitorosteoporosisarthritisbone metastasisInhibitorinhibitorinhibit

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HY-144812
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