2. Neuronal Signaling Anti-infection
  3. Glucosylceramide Synthase (GCS) Bacterial
  4. G43

G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study.

For research use only. We do not sell to patients.

G43 Chemical Structure

G43 Chemical Structure

CAS No. : 690693-02-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

G43 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study[1][2].

In Vitro

G43 (16 h) inhibits more than 85% of S. mutans biofilm at 12.5 μM[1].
G43 (25 μM, 24 h) reduces the glucan production by the glucosyltransferase (Gtfs), and consistently inhibits the activity of both GtfB and GtfC with 80% inhibition of both enzymes[1].
G43 (up to 25 μM, 24 h) shows no significant difference on expression of gtfs (gtfB, gtfC and gtfD) in S. mutans. UA159 cells[1].
G43 (50 μM, 24-48 h) reduces the biofilm formation by decreasing the production of Water-insoluble extracellular polysaccharide in wild-type S. mutans[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

G43 Related Antibodies

RT-PCR[1]

Cell Line: S. mutans. UA159 cells
Concentration: 3.125, 6.25, 12, 25 μM
Incubation Time: 24 h
Result: Showed no significant difference on expression of gtfs (gtfB, gtfC and gtfD).
In Vivo

G43 (100 µM twice daily for 4 weeks, topically administration) reduces S. mutans virulence in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The rat model of dental caries infected with S. mutans UA159[1]
Dosage: 100 µM twice daily for 4 weeks
Administration: Topically administration
Result: Reduced the buccal, sulcal, and proximal surface caries scores, but did not lose weight over the course of the study.
Molecular Weight

341.34

Formula

C16H11N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC2=C(S1)C=CC([N+]([O-])=O)=C2)NC3=CC=CC=C3C(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (58.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9296 mL 14.6482 mL 29.2963 mL
5 mM 0.5859 mL 2.9296 mL 5.8593 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9296 mL 14.6482 mL 29.2963 mL 73.2408 mL
5 mM 0.5859 mL 2.9296 mL 5.8593 mL 14.6482 mL
10 mM 0.2930 mL 1.4648 mL 2.9296 mL 7.3241 mL
15 mM 0.1953 mL 0.9765 mL 1.9531 mL 4.8827 mL
20 mM 0.1465 mL 0.7324 mL 1.4648 mL 3.6620 mL
25 mM 0.1172 mL 0.5859 mL 1.1719 mL 2.9296 mL
30 mM 0.0977 mL 0.4883 mL 0.9765 mL 2.4414 mL
40 mM 0.0732 mL 0.3662 mL 0.7324 mL 1.8310 mL
50 mM 0.0586 mL 0.2930 mL 0.5859 mL 1.4648 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

G43 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G43690693-02-8G 43G-43Glucosylceramide Synthase (GCS)BacterialS. mutans. UA159AntibacterialDental cariesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
G43
Cat. No.:
HY-155715
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.