G7-18NATE

Cat. No.: HY-P10224: FAQs
Data Sheet Handling Instructions

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G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (K_D = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines.

For research use only. We do not sell to patients.

G7-18NATE Chemical Structure

CAS No. : 936728-13-1

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Description	G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (K_D = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines^[1]^[2].
In Vitro	G7-18NATE (10 μM, 24 h) inhibits cell migration in MDA-MB-468 cells^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. G7-18NATE Related Antibodies
Molecular Weight	1417.50
Formula	C₆₇H₈₀N₁₄O₁₉S
CAS No.	936728-13-1
Sequence	cyclo(CH2CO-Trp-Phe-Glu-Gly-Tyr-Asp-Asn-Thr-Phe-Pro-Cys(NH2)-S-)
Sequence Shortening	cyclo(CH2CO-WFEGYDNTFP-Cys(NH2)-S-)
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (258 KB) Handling Instructions (2659 KB)
References	[1]. Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24(20):3739. [Content Brief] [2]. Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133(2):607-15. [Content Brief]

G7-18NATE Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G7-18NATE936728-13-1OthersanticancerpeptideInhibitorinhibitorinhibit

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