G7-18NATE TFA 

G7-18NATE TFA is a peptide inhibitor of Grb7. G7-18NATE TFA binds to the Grb7-SH2 domain with micromolar affinity (K_d = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines^[1][2].

G7-18NATE (10 μM, 24 h) inhibits cell migration in MDA-MB-468 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1417.50 (free base)

C₆₇H₈₀N₁₄O₁₉S.xC₂HF₃O₂

Solid

White to off-white

cyclo(CH2CO-Trp-Phe-Glu-Gly-Tyr-Asp-Asn-Thr-Phe-Pro-Cys(NH2)-S-)

cyclo(CH2CO-WFEGYDNTFP-Cys(NH2)-S-)

OC(C(F)(F)F)=O.O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(N[C@@H](CSC5)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6=CNC7=CC=CC=C67)NC5=O.[x]

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24(20):3739.  [Content Brief]

  [2]. Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133(2):607-15.  [Content Brief]