2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. GABAA receptor modular-3

GABAA receptor modular-3 (Compound S28) is a modulator for (γ-aminobutyric acid)A receptor (GABAA receptor), with EC50 of 56 nM and 10 nM, for α1β2γ2 and α4β3δ subtype. GABAA receptor modular-3 exhibits good pharmacokinetic characteristics in rats. GABAA receptor modular-3 is slightly toxic toxicity in rats with a loss of rollover reflex (LORR) threshold dose of 23.3 μmol/kg, and exhibits potential ameliorating the postpartum depression.

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GABAA receptor modular-3 Chemical Structure

GABAA receptor modular-3 Chemical Structure

CAS No. : 3021554-08-2

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GABAA receptor modular-3 Related Antibodies

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Description

GABAA receptor modular-3 (Compound S28) is a modulator for (γ-aminobutyric acid)A receptor (GABAA receptor), with EC50 of 56 nM and 10 nM, for α1β2γ2 and α4β3δ subtype. GABAA receptor modular-3 exhibits good pharmacokinetic characteristics in rats. GABAA receptor modular-3 is slightly toxic toxicity in rats with a loss of rollover reflex (LORR) threshold dose of 23.3 μmol/kg, and exhibits potential ameliorating the postpartum depression[1].

IC50 & Target

EC50: 56 nM (GABAA receptor α1β2γ2); 10 nM (GABAA receptor α4β3δ)
Molecular Weight

514.61

Formula

C28H36F2N4O3
CAS No.
SMILES

C[C@@]12[C@](CC[C@@H]2C(CN3C=NN(C4=CC(F)=NC(F)=C4)C3=O)=O)([H])[C@]5([H])CC[C@]6([H])C[C@@](O)(C)CC[C@]6([H])[C@@]5([H])CC1
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References
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GABAA receptor modular-3 Related Classifications

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Keywords:

GABAA receptor modular-33021554-08-2GABAA receptor modular3GABAA receptor modular 3GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorPPDpostpartum depressionSprague-Dawley ratInhibitorinhibitorinhibit

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