2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease PI3K/Akt/mTOR JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. HSP Akt EGFR
  4. Gamendazole

Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research.

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Gamendazole Chemical Structure

Gamendazole Chemical Structure

CAS No. : 877773-32-5

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Gamendazole Related Antibodies

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Description

Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research[1][2].

IC50 & Target[1]

HSP90AB1

 

EEF1A1

 

Akt1

 

ErbB2

 

Molecular Weight

415.19

Formula

C18H11Cl2F3N2O2
CAS No.
SMILES

O=C(/C=C/C1=NN(C2=C1C=CC(C(F)(F)F)=C2)CC3=CC=C(C=C3Cl)Cl)O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gamendazole Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gamendazole877773-32-5HSPAktEGFRHeat shock proteinsPKBProtein kinase BEpidermal growth factor receptorErbB-1HER1indazole carboxylic acidICAHSP90AB1EEF1A1AKT1ERBB2antispermatogenicantifertilitycontraceptive agentInhibitorinhibitorinhibit

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