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  4. Ganglioside GM3

Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia.

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Ganglioside GM3 Chemical Structure

Ganglioside GM3 Chemical Structure

CAS No. : 124579-05-1

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1 mg USD 620 In-stock
5 mg USD 2180 In-stock
10 mg USD 3400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ganglioside GM3:

Ganglioside GM3 Related Antibodies

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  • Purity & Documentation

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Description

Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia[1].

In Vitro

Ganglioside GM3, produced by addition of sialic acid to LacCer, is expressed mainly in adipose tissue and muscle in humans and mice, and liver and serum in humans. GM3 expression in adipocytes is induced by stimulation of the inflammatory cytokines TNF-α and IL-1β, derived from tissue macrophages[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ganglioside GM3 Related Antibodies
Molecular Weight

1181.49

Formula

C59H108N2O21
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@]1(O[C@@]([C@H](NC(C)=O)[C@@H](O)C1)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@H](CO)[C@@H]2O)O[C@]3([H])[C@H](O[C@@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC)=O)[C@H](O)[C@H]3O)CO)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (105.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8464 mL 4.2319 mL 8.4639 mL
5 mM 0.1693 mL 0.8464 mL 1.6928 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.07%

SDS (252 KB)

COA (249 KB) HNMR (327 KB) RP-HPLC (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8464 mL 4.2319 mL 8.4639 mL 21.1597 mL
5 mM 0.1693 mL 0.8464 mL 1.6928 mL 4.2319 mL
10 mM 0.0846 mL 0.4232 mL 0.8464 mL 2.1160 mL
15 mM 0.0564 mL 0.2821 mL 0.5643 mL 1.4106 mL
20 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0580 mL
25 mM 0.0339 mL 0.1693 mL 0.3386 mL 0.8464 mL
30 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.7053 mL
40 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5290 mL
50 mM 0.0169 mL 0.0846 mL 0.1693 mL 0.4232 mL
60 mM 0.0141 mL 0.0705 mL 0.1411 mL 0.3527 mL
80 mM 0.0106 mL 0.0529 mL 0.1058 mL 0.2645 mL
100 mM 0.0085 mL 0.0423 mL 0.0846 mL 0.2116 mL
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Ganglioside GM3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganglioside GM3124579-05-1Ganglioside GM 3Ganglioside GM-3OthershypercholesterolemiagangliosidesmonosialodihexosylgangliosideInhibitorinhibitorinhibit

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