2. GPCR/G Protein
  3. GnRH Receptor
  4. Ganirelix

Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ganirelix Chemical Structure

Ganirelix Chemical Structure

CAS No. : 124904-93-4

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Based on 1 publication(s) in Google Scholar

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Ganirelix Related Antibodies

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Description

Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea[1].

In Vivo

Ganirelix (0.1 mg/kg; s.c.; daily for 14 d) reduces luteinising hormone levels in female rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley rats, weighing 225–300 mg[2]
Dosage: 0.1 mg/kg
Administration: Subcutaneous injection, daily for 14 d
Result: Reduced luteinising hormone levels.
Clinical Trial
Molecular Weight

1570.32

Formula

C80H113ClN18O13
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-{Har(Et,Et)}-Leu-{Har(Et,Et)}-Pro-D-Ala-NH2
Sequence Shortening

Ac-{D-2Nal}-{D-Phe(4-Cl)}-{D-3Pal}-SY-{D-Har(Et,Et)}-L-{Har(Et,Et)}-P-{D-Ala}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (15.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6368 mL 3.1841 mL 6.3681 mL
5 mM 0.1274 mL 0.6368 mL 1.2736 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6368 mL 3.1841 mL 6.3681 mL 15.9203 mL
5 mM 0.1274 mL 0.6368 mL 1.2736 mL 3.1841 mL
10 mM 0.0637 mL 0.3184 mL 0.6368 mL 1.5920 mL
15 mM 0.0425 mL 0.2123 mL 0.4245 mL 1.0614 mL
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Ganirelix Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganirelix124904-93-4GnRH ReceptorGonadotropin releasing hormone receptorGNRHRluteinising hormoneLHgonadotropin releasing hormonehormone releaInhibitorinhibitorinhibit

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