Ganoderic acid TR

Cat. No.: HY-129150 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H5N1 and H1N1 neuraminidases. The IC₅₀ values of 10.9 and 4.6 μM, respectively.

For research use only. We do not sell to patients.

Ganoderic acid TR Chemical Structure

CAS No. : 862893-75-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H5N1 and H1N1 neuraminidases. The IC₅₀ values of 10.9 and 4.6 μM, respectively^[1].

IC₅₀ & Target

IC50: 10.9 (H5N1), 4.6 μM (H1N1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC₅₀	> 107 μM Compound: 33	Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 26716912]

Molecular Weight

468.67

Formula

C₃₀H₄₄O₄

CAS No.

862893-75-2

Appearance

Solid

Color

White to off-white

SMILES

CC1(C)C(CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC/C=C(C)/C(O)=O)C[C@H](O)[C@](C)4C3=CC[C@@]12[H])=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5.5 mg/mL (11.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1337 mL	10.6685 mL	21.3370 mL
5 mM	0.4267 mL	2.1337 mL	4.2674 mL
10 mM	0.2134 mL	1.0668 mL	2.1337 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Zhu Q, et al. Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design. Sci Rep. 2015 Aug 26;5:13194. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1337 mL	10.6685 mL	21.3370 mL	53.3424 mL
	5 mM	0.4267 mL	2.1337 mL	4.2674 mL	10.6685 mL
	10 mM	0.2134 mL	1.0668 mL	2.1337 mL	5.3342 mL