Gefitinib-d₈ (Synonyms: ZD1839-d₈)

Cat. No.: HY-50895S Purity: 98.42%: FAQs
Data Sheet SDS COA Handling Instructions

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Gefitinib-d₈ is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

For research use only. We do not sell to patients.

Gefitinib-d<sub>8</sub> Chemical Structure

Gefitinib-d₈ Chemical Structure

CAS No. : 857091-32-8

Size	Price	Stock	Quantity
1 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Gefitinib-d₈:

Gefitinib In-stock

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Description

Gefitinib-d₈ is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

IC₅₀ & Target

IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)^[1]

Molecular Weight

454.95

Formula

C₂₂H₁₆D₈ClFN₄O₃

CAS No.

857091-32-8

Unlabeled CAS

184475-35-2

Appearance

Solid

Color

White to off-white

SMILES

[2H]C1([2H])OC([2H])([2H])C([2H])([2H])N(CCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)C1([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (274.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1980 mL	10.9902 mL	21.9804 mL
5 mM	0.4396 mL	2.1980 mL	4.3961 mL
10 mM	0.2198 mL	1.0990 mL	2.1980 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.42%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23. [Content Brief]

[2]. Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	2.1980 mL	10.9902 mL	21.9804 mL	54.9511 mL
	5 mM	0.4396 mL	2.1980 mL	4.3961 mL	10.9902 mL
	10 mM	0.2198 mL	1.0990 mL	2.1980 mL	5.4951 mL
	15 mM	0.1465 mL	0.7327 mL	1.4654 mL	3.6634 mL
	20 mM	0.1099 mL	0.5495 mL	1.0990 mL	2.7476 mL
	25 mM	0.0879 mL	0.4396 mL	0.8792 mL	2.1980 mL
	30 mM	0.0733 mL	0.3663 mL	0.7327 mL	1.8317 mL
	40 mM	0.0550 mL	0.2748 mL	0.5495 mL	1.3738 mL
	50 mM	0.0440 mL	0.2198 mL	0.4396 mL	1.0990 mL
	60 mM	0.0366 mL	0.1832 mL	0.3663 mL	0.9159 mL
	80 mM	0.0275 mL	0.1374 mL	0.2748 mL	0.6869 mL
	100 mM	0.0220 mL	0.1099 mL	0.2198 mL	0.5495 mL

Gefitinib-d₈ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gefitinib-d₈857091-32-8ZD1839-d₈EGFRAutophagyEpidermal growth factor receptorErbB-1HER1DeuteriumlabeledGefitinibInhibitorinhibitorinhibit

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Gefitinib-d8 (Synonyms: ZD1839-d8)

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View All EGFR Isoform Specific Products:

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Complete Stock Solution Preparation Table

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Gefitinib-d₈ (Synonyms: ZD1839-d₈)

Other Forms of Gefitinib-d₈:

Gefitinib-d₈ Related Antibodies

Gefitinib-d₈ Related Classifications