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GEMSA  (Synonyms: 2-Guanidinoethylmercaptosuccinic acid)

Cat. No.: HY-118120
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GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia.

For research use only. We do not sell to patients.

GEMSA Chemical Structure

GEMSA Chemical Structure

CAS No. : 77482-44-1

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Based on 1 publication(s) in Google Scholar

GEMSA Related Antibodies

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Description

GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1].

IC50 & Target

Encephalin convertase, Ki 值为8.8 nM.
In Vitro

GEMSA inhibits the activation of TAFI and porcine CBB[1].
GEMSA can inhibit the prolongation of lysis time in recombinant BAP and does not lead to the lysis of APC fibronectin[1].
GEMSA inhibits the prolongation of lysis time in porcine CPB, TAFI, and recombinant BAP, APC with the EC50 values of 0.34 μM, 100μM, 115 μM, 90 μM respectively[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GEMSA Related Antibodies
In Vivo

GEMSA (ICV, 0.1μg/mg, every, 3days) results in a 75% increase in hypothalamic luteinizing hormone-releasing hormone and serum luteinizing hormone levels, and a 60% decrease in serum prolactin concentrations in rat[3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

235.26

Formula

C7H13N3O4S
CAS No.
SMILES

OC(C(SCCNC(N)=N)CC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GEMSA Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GEMSA77482-44-12-Guanidinoethylmercaptosuccinic acidOthersenkephalin convertaseanalgesiaInhibitorinhibitorinhibit

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