2. Gene
  3. PARP3 - poly(ADP-ribose) polymerase family member 3 Gene

PARP3 - poly(ADP-ribose) polymerase family member 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3

Gene ID: 10039 | Gene type: protein coding

About PARP3

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,942,363-51,948,867 (from NCBI)

This gene has 9 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the PARP family. These Enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of Apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PARP3 Products(6)

mRNA Protein Name
NM_001370239.1 NP_001357168.1 protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001370240.1 NP_001357169.1 protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_005485.6 NP_005476.4 protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003931.4 NP_001003931.4 protein mono-ADP-ribosyltransferase PARP3 isoform a
NM_001003935.2
XM_047447087.1 XP_047303043.1 protein mono-ADP-ribosyltransferase PARP3 isoform X1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NAD DNA ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
29361132 GOA
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
20064938 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
21211721 GOA
enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
20064938 GOA
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
20064938 GOA
enables NAD+-protein-lysine ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
25043379 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20064938 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA ADP-ribosylation IDA
IDA: Inferred from direct assay
29361132 GOA
acts upstream of or within double-strand break repair IDA
IDA: Inferred from direct assay
21270334 GOA
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
21211721 GOA
acts upstream of or within positive regulation of DNA ligation IGI
IGI: Inferred from genetic interaction
21211721 GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining IDA
IDA: Inferred from direct assay
24598253 GOA
involved in protein auto-ADP-ribosylation IDA
IDA: Inferred from direct assay
25043379 GOA
acts upstream of or within protein localization to site of double-strand break IMP
IMP: Inferred from mutant phenotype
21211721 GOA
NOT involved in protein poly-ADP-ribosylation IDA
IDA: Inferred from direct assay
25043379 GOA
acts upstream of or within regulation of mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
21270334 GOA
acts upstream of or within telomere maintenance IMP
IMP: Inferred from mutant phenotype
21270334 GOA
Cellular Component GO Annotation Evidence Reference Source
located in site of double-strand break IDA
IDA: Inferred from direct assay
21270334 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP3 Protein Structure

WGR

WGR: WGR domain (64 - 143)

PARP_reg

PARP_reg: Poly(ADP-ribose) polymerase, regulatory domain (183 - 320)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (322 - 532)

  • 0
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  • 400
  • 500
  • 533 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP3

ADP-ribosyltransferase (NAD+

poly (ADP-ribose) polymerase)-like 2

ADP-ribosyltransferase (NAD+

poly (ADP-ribose) polymerase)-like 3

ADP-ribosyltransferase diphtheria toxin-like 3

ADPRT-3

DNA ADP-ribosyltransferase PARP3

NAD(+) ADP-ribosyltransferase 3

NAD+ ADP-ribosyltransferase 3

poly [ADP-ribose] polymerase 3

poly(ADP-ribose) synthetase-3

poly[ADP-ribose] synthase 3

poly[ADP-ribose] synthetase 3

Related Diseases

Diseases Alias
Alcohol-Related Birth Defects

Arbd

Alcohol-Related Birth Defect

Alcohol Related Birth Defect

Fetal Alcohol Syndrome
Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10617A Rucaparib Inhibitor 99.97% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-10619A Niraparib hydrochloride Inhibitor 99.41% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13536 AZD-2461 Inhibitor 99.88% Phase 1
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150207 RBN-3143 Inhibitor 99.24% Unkown
HY-148566 OUL232 Inhibitor 99.86% Unkown
HY-100225 ME0328 Inhibitor 99.64% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.89% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.02% Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-100847 AZ0108 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PARP3 VGNC VGNC:80647
Macaca mulatta PARP3 VGNC VGNC:84055
Mus musculus PARP3 MGD MGI:1891258
Rattus norvegicus PARP3 RGD RGD:1305189
Canis familiaris PARP3 VGNC VGNC:81897
Others PARP3 NCBI