SH2D3C - SH2 domain containing 3C Gene

Homo sapiens

Also known as CHAT; NSP3; SHEP1; PRO34088

Gene ID: 10044 | Gene type: protein coding

About SH2D3C

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,738,317-127,778,666 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 2 paralogues. Broad expression in spleen (RPKM 12.4), lung (RPKM 10.5) and 22 other tissues.

Summary

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SH2D3C Products(7)

mRNA	Protein	Name
NM_001142531.1	NP_001136003.1	SH2 domain-containing protein 3C isoform c
NM_001142532.1	NP_001136004.1	SH2 domain-containing protein 3C isoform c
NM_001142533.1	NP_001136005.1	SH2 domain-containing protein 3C isoform d
NM_001142534.1	NP_001136006.1	SH2 domain-containing protein 3C isoform e
NM_001252334.2	NP_001239263.1	SH2 domain-containing protein 3C isoform f
NM_005489.4	NP_005480.2	SH2 domain-containing protein 3C isoform b
NM_170600.3	NP_733745.1	SH2 domain-containing protein 3C isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22081014	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2D3C Protein Structure

SH2

RasGEF

0
200
400
600
800
860 a.a.

Protein Preferred Names

Protein Names

SH2 domain-containing protein 3C

SH2 domain-containing Eph receptor-binding protein 1

Related Diseases

Diseases

Alias

Eastern Equine Encephalitis

Eee	Neuroinvasive Eastern Equine Encephalitis Virus Infection
Eastern Equine Encephalomyelitis	Encephalomyelitis, Eastern Equine
Triple E	Eastern Equine Encephalitis Virus Infection
Neuroinvasive Eastern Equine Encephalitis Virus Disease	Eee - [Eastern Equine Encephalitis]

Western Equine Encephalitis

Western Equine Encephalomyelitis	Wee
Encephalomyelitis, Western Equine	Western Equine Encephalitis Virus Infection
Wee - [Western Equine Encephalitis]	Western Equine Encephalitis Virus

Blue Toe Syndrome

Noonan Syndrome 12

NS12

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Ross River Fever

Ross River Virus Disease

Ross River Virus Infection

Noonan Syndrome 7

NS7	Noonan Syndrome, Type 7

Acute Diarrhea

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Griscelli Syndrome, Type 3

Griscelli Syndrome Type 3	GS3
Griscelli-Prunieras Syndrome Type 3	Hypomelanosis With No Immunologic Or Neurologic Manifestations
Griscelli Syndrome 3

Coronavirus Infectious Disease

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12824	SH2D3C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SH2D3C	MGD	MGI:1351631
Macaca mulatta	SH2D3C	VGNC	VGNC:77253
Rattus norvegicus	SH2D3C	RGD	RGD:1307287
Bos taurus	SH2D3C	VGNC	VGNC:34559
Canis familiaris	SH2D3C	VGNC	VGNC:46113
Felis catus	SH2D3C	VGNC	VGNC:65094

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