SMC4 - structural maintenance of chromosomes 4 Gene

Homo sapiens

Also known as CAPC; CAP-C; SMC-4; SMC4L1

Gene ID: 10051 | Gene type: protein coding

About SMC4

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:160,399,650-160,434,953 (from NCBI)

This gene has 27 transcripts (splice variants), 214 orthologues and 7 paralogues. Broad expression in testis (RPKM 22.9), bone marrow (RPKM 22.6) and 24 other tissues.

Summary

This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016]

SMC4 Products(3)

mRNA	Protein	Name
NM_001002800.3	NP_001002800.1	structural maintenance of chromosomes protein 4 isoform 1
NM_001288753.2	NP_001275682.1	structural maintenance of chromosomes protein 4 isoform 2
NM_005496.3	NP_005487.3	structural maintenance of chromosomes protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9789013	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic chromosome condensation	IDA IDA: Inferred from direct assay	11136719	GOA
involved in positive regulation of chromosome condensation	IDA IDA: Inferred from direct assay	17268547	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of condensin complex	IDA IDA: Inferred from direct assay	9789013	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMC4 Protein Structure

SMC_N

SMC_hinge

0
200
400
600
800
1000
1200
1288 a.a.

Protein Preferred Names

Protein Names

structural maintenance of chromosomes protein 4

SMC protein 4

SMC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMC4	Q9NTJ3	NCAPH2	Homo sapiens	Q6IBW4	Anti Bait CoIP	17268547
Intra	SMC4	Q9NTJ3	SMC2	Homo sapiens	O95347	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

SMC4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82595	SMC4 Antibody (YA2340)	WB, ICC/IF, FC	Human, Mouse

Related Diseases

Diseases

Alias

Pleural Empyema

Empyema	Pyothorax
Empyema, Pleural	Abscess Of Pleural Cavity
Abscess Of Thorax	Empyema Of Pleura
Empyema Of Pleura Without Fistula	Empyema With Fistula
Empyema With No Fistula	Empyema With Pleural Fistula
Empyema Without Mention Of Fistula	Empyema, Chest
Lung Empyema	Pleural Empyema With Fistula
Pleural Empyema With No Fistula	Purulent Pleurisy
Purulent Pleuritis	Thorax Abscess
Pyopneumothorax

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13420	SMC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SMC4	VGNC	VGNC:65478
Canis familiaris	SMC4	VGNC	VGNC:46545
Macaca mulatta	SMC4	VGNC	VGNC:77699
Mus musculus	SMC4	MGD	MGI:1917349
Rattus norvegicus	SMC4	RGD	RGD:1306680
Bos taurus	SMC4	VGNC	VGNC:35001

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