PTPRU - protein tyrosine phosphatase receptor type U Gene

Homo sapiens

Also known as FMI; PTP; PCP-2; PTP-J; PTPRO; PTPU2; PTP-PI; PTP-RO; PTPPSI; hPTP-J; R-PTP-U; R-PTP-PSI

Gene ID: 10076 | Gene type: protein coding

About PTPRU

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:29,236,522-29,326,800 (from NCBI)

This gene has 11 transcripts (splice variants), 279 orthologues and 35 paralogues. Broad expression in placenta (RPKM 9.6), lung (RPKM 7.2) and 21 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]

PTPRU Products(4)

mRNA	Protein	Name
NM_001195001.2	NP_001181930.1	receptor-type tyrosine-protein phosphatase U isoform 4 precursor
NM_005704.5	NP_005695.3	receptor-type tyrosine-protein phosphatase U isoform 3 precursor
NM_133177.4	NP_573438.3	receptor-type tyrosine-protein phosphatase U isoform 2 precursor
NM_133178.4	NP_573439.2	receptor-type tyrosine-protein phosphatase U isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	16574648	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10397721	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	12501215	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	16574648	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16574648	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	12501215	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16574648	GOA
involved in positive regulation of cell-cell adhesion mediated by cadherin	IDA IDA: Inferred from direct assay	16574648	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	12501215	GOA
involved in protein localization to cell surface	IDA IDA: Inferred from direct assay	16574648	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	12501215	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRU Protein Structure

MAM

fn3

Y_phosphatase

0
300
600
900
1200
1446 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase U

PTP pi

PTPRU Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPRU	Q92729	KIT	Homo sapiens	P10721	Anti Bait CoIP	10397721

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Plague

Yersiniosis	Yersinia Infections
Infection By Yersinia Pestis	Pasteurella Pestis Infection
Pestilential Fever	Yersinia Pestis Infection

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Myasthenic Syndrome, Congenital, 6, Presynaptic

Familial Infantile Myasthenia	CMS6
Cmsea	Congenital Myasthenic Syndrome 6
Familial Infantile Myasthenia Gravis 2	Fimg2
Myasthenic Syndrome, Congenital, Associated With Episodic Apnea	Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea
Congenital Myasthenic Syndrome Type Ia2, Formerly	Cms1a2, Formerly
Cms Ia2, Formerly	Myasthenia, Familial Infantile, Formerly
Fim, Formerly	Myasthenia Gravis, Familial Infantile, 2, Formerly
Fimg2, Formerly	Cms Ia2
Cms1a2	Congenital Myasthenic Syndrome 6, Presynaptic
Congenital Myasthenic Syndrome Type Ia2	Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea
Fim	Cms1a
Cms-Ea	Cms Ia
Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea	Congenital Myasthenic Syndrome Type 1a
Congenital Myasthenic Syndrome Type Ia	Myasthenic Syndrome, Congenital, Type 6, Presynaptic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11451	PTPRU Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPRU	VGNC	VGNC:45200
Macaca mulatta	PTPRU	VGNC	VGNC:76624
Bos taurus	PTPRU	VGNC	VGNC:33559
Mus musculus	PTPRU	MGD	MGI:1321151
Rattus norvegicus	PTPRU	RGD	RGD:620782
Felis catus	PTPRU	VGNC	VGNC:69183

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