2. Gene
  3. TSPAN1 - tetraspanin 1 Gene

TSPAN1 - tetraspanin 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NET1; TM4C; TM4SF

Gene ID: 10103 | Gene type: protein coding

About TSPAN1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:46,175,087-46,196,489 (from NCBI)

This gene has 9 transcripts (splice variants), 194 orthologues and 32 paralogues. Biased expression in colon (RPKM 237.8), prostate (RPKM 118.0) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

TSPAN1 Products(1)

mRNA Protein Name
NM_005727.4 NP_005718.2 tetraspanin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21836059 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein stabilization IDA
IDA: Inferred from direct assay
21836059 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12115476 GOA
located in membrane IDA
IDA: Inferred from direct assay
12115476 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
22378020 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21836059 GOA
located in vesicle IDA
IDA: Inferred from direct assay
21836059 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN1 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (6 - 239)

  • 0
  • 100
  • 200
  • 241 a.a.
Protein Preferred Names Protein Names

tetraspanin-1

tetraspan 1

TSPAN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TSPAN1 O60635 TFAM Homo sapiens Q00059
Validated Y2H
32296183
Intra
TSPAN1 O60635 TFAM Homo sapiens Q00059
Y2H Array
32296183
Intra
TSPAN1 O60635 TFAM Homo sapiens Q00059
Y2H Prey Pooling
32296183
Intra
TSPAN1 O60635 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
TSPAN1 O60635 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
TSPAN1 O60635 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
TSPAN1 O60635 SLC19A2 Homo sapiens O60779
Pull Down
21836059
Intra
TSPAN1 O60635 SLC19A2 Homo sapiens O60779
Y2H
21836059
Intra
TSPAN1 O60635 SLC19A2 Homo sapiens O60779
Anti Tag CoIP
21836059
Intra
TSPAN1 O60635 SLC19A2 Homo sapiens O60779
Confocal
21836059
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TSPAN1 Proteins

Cat. No. Product Name Accession Purity
HY-P77260 TSPAN1 Protein, Human (HEK293, His) O60635 (Y110-N211) ≥95%
HY-P77261 TSPAN1 Protein, Human (HEK293, rFc) O60635 (Y110-N211) ≥95%
HY-P77262 TSPAN1 Protein, Human (HEK293, Fc) O60635 (Y110-N211) ≥95%

Related Diseases

Diseases Alias
Retinitis Pigmentosa 76

RP76

Retinitis Pigmentosa, Type 76
Muscle Eye Brain Disease

Muscle-Eye-Brain Disease

Muscle-Eye-Brain Syndrome

Meb

Muscular Dystrophy-Dystroglycanopathy Congenital With Brain And Eye Anomalies A3

Meb Syndrome

Santavuori Congenital Muscular Dystrophy
Muscular Dystrophy-Dystroglycanopathy , Type B, 3

MDDGB3

Muscular Dystrophy-Dystroglycanopathy , Type B3

Muscular Dystrophy, Congenital, Pomgnt1-Related

Muscular Dystrophy-Dystroglycanopathy Type B3

Congenital Muscular Dystrophy Pomgnt1-Related

Muscular Dystrophy-Dystroglycanopathy Congenital With Impaired Intellectual Development B3

Muscular Dystrophy Congenital Pomgnt1-Related

Dystrophy, Muscular, Dystroglycanopathy , Type B3
Muscular Dystrophy-Dystroglycanopathy , Type C, 3

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2o

MDDGC3

Lgmd2o

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 15

Lgmdr15

Muscular Dystrophy-Dystroglycanopathy Limb-Girdle Pomgnt1-Related

Muscular Dystrophy, Limb-Girdle, Type 2o

Muscular Dystrophy-Dystroglycanopathy, Limb-Girdle, Pomgnt1-Related

Muscular Dystrophy-Dystroglycanopathy Type C3

Pomgnt1-Related Limb-Girdle Muscular Dystrophy R15

Lgmd Type 2o

Limb-Girdle Muscular Dystrophy Type 2o

Pomgnt1-Related Lgmd R15

Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C3

Dystrophy, Muscular, Limb-Girdle, Type 2o
Congenital Muscular Dystrophy-Dystroglycanopathy Type A3

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A3

Mddga3

Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Pomgnt1-Related

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A3
Muscular Dystrophy-Dystroglycanopathy , Type A, 3

MDDGA3

Muscular Dystrophy-Dystroglycanopathy , Type A3

Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Pomgnt1-Related

Muscular Dystrophy-Dystroglycanopathy Congenital With Brain And Eye Anomalies A3

Muscle-Eye-Brain Disease Pomgnt1-Related

Walker-Warburg Syndrome Pomgnt1-Related

Dystrophy, Muscular, Dystroglycanopathy , Type A3
Congenital Muscular Dystrophy-Dystroglycanopathy Type A

Congenital Muscular Alpha-Dystroglycanopathy With Brain And Eye Anomalies

Mddga

Klissencephaly Type 2 With Muscular And Ocular Involvement

Lissencephaly Type 2 With Muscular And Ocular Involvement
Muscular Dystrophy-Dystroglycanopathy

Cmd Due To Dystroglycanopathy

Congenital Muscular Dystrophy Due To Dystroglycanopathy

Mddg

Dystrophy, Muscular, Dystroglycanopathy
Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Abnormality Of Glucagon Secretion

Glucagon Secretion Abnormality

Abnormality Of Secretion Of Glucagon
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Usher Syndrome, Type Iiia

Usher Syndrome Type 3

Ush3

Usher Syndrome Type 3a

USH3A

Usher Syndrome, Type Iii

Usher Syndrome, Type 3

Usher Syndrome, Type 3a

Usher Syndrome Type Iiia

Usher Syndrome 3a

Usher'S Syndrome Type 3

Usher Syndrome Iii

Usher Syndrome Type Iii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15157 TSPAN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TSPAN1 RGD RGD:1303308
Canis familiaris TSPAN1 VGNC VGNC:47910
Felis catus TSPAN1 VGNC VGNC:66624
Mus musculus TSPAN1 MGD MGI:1914055
Bos taurus TSPAN1 VGNC VGNC:36425
Macaca mulatta TSPAN1 VGNC VGNC:79263
Others TSPAN1 NCBI