TRIM10 - tripartite motif containing 10 Gene

Homo sapiens

Also known as RNF9; HERF1; RFB30

Gene ID: 10107 | Gene type: protein coding

About TRIM10

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,151,943-30,164,009 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 96 orthologues and 80 paralogues. Biased expression in bone marrow (RPKM 6.5), kidney (RPKM 1.8) and 6 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TRIM10 Products(2)

mRNA	Protein	Name
NM_006778.4	NP_006769.2	tripartite motif-containing protein 10 isoform 1
NM_052828.3	NP_439893.2	tripartite motif-containing protein 10 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM10 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

0
100
200
300
395 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 10

B30-RING finger protein

TRIM10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM10	Q9UDY6	ZNF148	Homo sapiens	Q9UQR1	Y2H Prey Pooling	25416956
Intra	TRIM10	Q9UDY6	ZNF148	Homo sapiens	Q9UQR1	Validated Y2H	25416956
Intra	TRIM10	Q9UDY6	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	TRIM10	Q9UDY6	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	TRIM10	Q9UDY6	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	TRIM10	Q9UDY6	TTC23	Homo sapiens	Q5W5X9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15019	TRIM10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIM10	MGD	MGI:1338757
Canis familiaris	TRIM10	VGNC	VGNC:49639
Rattus norvegicus	TRIM10	RGD	RGD:1359438
Bos taurus	TRIM10	VGNC	VGNC:36312
Macaca mulatta	TRIM10	VGNC	VGNC:78550

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