ARPC2 - actin related protein 2/3 complex subunit 2 Gene

Homo sapiens

Also known as ARC34; PRO2446; p34-Arc; PNAS-139

Gene ID: 10109 | Gene type: protein coding

About ARPC2

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,217,189-218,254,348 (from NCBI)

This gene has 18 transcripts (splice variants) and 240 orthologues. Ubiquitous expression in lymph node (RPKM 92.4), bone marrow (RPKM 89.6) and 25 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

ARPC2 Products(4)

mRNA	Protein	Name
NM_152862.3	NP_690601.1	actin-related protein 2/3 complex subunit 2
XM_017003113.2	XP_016858602.1	actin-related protein 2/3 complex subunit 2 isoform X1
NM_005731.3	NP_005722.1	actin-related protein 2/3 complex subunit 2
XM_047442808.1	XP_047298764.1	actin-related protein 2/3 complex subunit 2 isoform X2

ARPC2 Protein Structure

P34-Arc

0
100
200
300 a.a.

Protein Preferred Names

Protein Names

actin-related protein 2/3 complex subunit 2

ARP2/3 protein complex subunit 34	actin related protein 2/3 complex, subunit 2, 34kDa
arp2/3 complex 34 kDa subunit	testis tissue sperm-binding protein Li 53e

Related Diseases

Diseases

Alias

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Inclusion Conjunctivitis

Chlamydial Conjunctivitis	Inclusion Blennorrhoea
Paratrachoma	Adult Inclusion Conjunctivitis
Inclusion Blenorrhea	Conjunctivitis, Inclusion
Neonatal Chlamydial Conjunctivitis	Inclusion Conjunctivitis Of The Adult
Chronic Conjunctivitis Due To Chlamydia Trachomatis	Inclusion Conjunctivitis Due To Chlamydia Trachomatis
Acute Follicular Conjunctivitis, Chlamydial	Adult Chlamydial Keratoconjunctivitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114657A	Benproperine phosphate	Inhibitor	99.35%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01015	ARPC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01016	Arpc2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01017	Arpc2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARPC2	VGNC	VGNC:82525
Mus musculus	ARPC2	MGD	MGI:1923959
Rattus norvegicus	ARPC2	RGD	RGD:1305848
Macaca mulatta	ARPC2	VGNC	VGNC:70019
Bos taurus	ARPC2	VGNC	VGNC:55326

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