KIF20A - kinesin family member 20A Gene

Homo sapiens

Also known as RCM6; MKLP2; RAB6KIFL

Gene ID: 10112 | Gene type: protein coding

About KIF20A

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,179,112-138,187,723 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 7.6), bone marrow (RPKM 5.2) and 14 other tissues.

Summary

Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Implicated in restrictive cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]

KIF20A Products(1)

mRNA	Protein	Name
NM_005733.3	NP_005724.1	kinesin-like protein KIF20A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16431929	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12939256	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in microtubule bundle formation	IDA IDA: Inferred from direct assay	12939256	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in regulation of cytokinesis	IDA IDA: Inferred from direct assay	12939256	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in midbody	IDA IDA: Inferred from direct assay	15843429	GOA
located in spindle	IDA IDA: Inferred from direct assay	12939256	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF20A Protein Structure

Kinesin

0
200
400
600
800
890 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF20A

GG10_2

KIF20A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KIF20A	O95235	ATOSB	Homo sapiens	Q7L5A3	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Restrictive, 6

RCM6	Cardiomyopathy, Familial Restrictive 6

Familial Isolated Restrictive Cardiomyopathy

Familial Or Idiopathic Restrictive Cardiomyopathy

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy	Cardiomyopathy, Restrictive
Cardiomyopathy, Constrictive	Primary Restrictive Cardiomyopathy
Rcm	Cardiomyopathy Restrictive

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07272	KIF20A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KIF20A	VGNC	VGNC:69205
Macaca mulatta	KIF20A	VGNC	VGNC:74037
Bos taurus	KIF20A	VGNC	VGNC:30594
Canis familiaris	KIF20A	VGNC	VGNC:42394
Mus musculus	KIF20A	MGD	MGI:1201682
Rattus norvegicus	KIF20A	RGD	RGD:1307695

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