Pot1a - protection of telomeres 1A Gene

Mus musculus

Also known as Pot1; 1500031H18Rik

Gene ID: 101185 | Gene type: protein coding

About Pot1a

Summary

Enables single-stranded telomeric DNA binding activity. Acts upstream of or within chromosome organization. Located in chromosome, telomeric region. Part of nuclear telomere cap complex. Is expressed in several structures, including basisphenoid bone; brain; genitourinary system; musculature; and otic capsule. Human ortholog(s) of this gene implicated in familial melanoma and high grade glioma. Orthologous to human POT1 (protection of telomeres 1). [provided by Alliance of Genome Resources, Apr 2022]

Pot1a Products(1)

mRNA	Protein	Name
NM_133931.5	NP_598692.1	protection of telomeres protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17053789	MGI
enables single-stranded telomeric DNA binding	IDA IDA: Inferred from direct assay	17053789	MGI
enables telomeric DNA binding	IDA IDA: Inferred from direct assay	19854130	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chromosome organization	IGI IGI: Inferred from genetic interaction	17053789	MGI
NOT involved in telomeric loop formation	IGI IGI: Inferred from genetic interaction	24120135	MGI
NOT involved in telomeric loop formation	IMP IMP: Inferred from mutant phenotype	24120135	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	23685356	MGI
part of nuclear telomere cap complex	IDA IDA: Inferred from direct assay	17053789	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protection of telomeres protein 1

POT1-like telomere end-binding protein

Pot1a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pot1	Q91WC1	Acd	Mus musculus	Q5EE38-1	CoIP	17632522
Intra	Pot1	Q91WC1	Tpp1	Mus musculus	O89023	Y2H	17053789
Cross	Pot1	Q91WC1	ACD	Homo sapiens	Q96AP0	CoIP	17632522

Cross: Cross-species interaction Intra: Intraspecies interaction

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