RBM12 - RNA binding motif protein 12 Gene

Homo sapiens

Also known as SWAN; SCZD19; HRIHFB2091

Gene ID: 10137 | Gene type: protein coding

About RBM12

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,648,925-35,664,900 (from NCBI)

This gene has 6 transcripts (splice variants), 126 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 14.4), ovary (RPKM 12.2) and 25 other tissues.

Summary

This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in four transcript variants. All variants encode the same protein. [provided by RefSeq, Nov 2010]

RBM12 Products(4)

mRNA	Protein	Name
NM_001198838.2	NP_001185767.1	RNA-binding protein 12
NM_001198840.2	NP_001185769.1	RNA-binding protein 12
NM_006047.6	NP_006038.2	RNA-binding protein 12
NM_152838.4	NP_690051.1	RNA-binding protein 12

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM12 Protein Structure

RRM_1

0
200
400
600
800
932 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein 12

SH3/WW domain anchor protein in the nucleus

RBM12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RBM12	Q9NTZ6	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Schizophrenia 19

SCZD19	Schizophrenia 19 With Or Without An Affective Disorder
Schizophrenia 19, Susceptibility To	{Schizophrenia 19, Susceptibility To}

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11733	RBM12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RBM12	MGD	MGI:1922960
Canis familiaris	RBM12	VGNC	VGNC:45406
Rattus norvegicus	RBM12	RGD	RGD:1594333
Bos taurus	RBM12	VGNC	VGNC:33785

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