1. Gene
  2. OPTN - optineurin Gene

OPTN - optineurin Gene

Homo sapiens

Also known as NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP

Gene ID: 10133 | Gene type: protein coding

About OPTN

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:13,100,082-13,138,308 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 6 phenotypes. Ubiquitous expression in fat (RPKM 52.0), adrenal (RPKM 41.0) and 25 other tissues.

Summary

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate Apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, Huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

OPTN Products(4)

mRNA Protein Name
NM_001008211.1 NP_001008212.1 optineurin
NM_001008212.2 NP_001008213.1 optineurin
NM_001008213.1 NP_001008214.1 optineurin
NM_021980.4 NP_068815.2 optineurin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23414517 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
21617041 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15837803 GOA
enables protein-macromolecule adaptor activity IPI
IPI: Inferred from physical interaction
25803835 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
15837803 GOA
involved in Golgi ribbon formation IDA
IDA: Inferred from direct assay
15837803 GOA
involved in Golgi ribbon formation IMP
IMP: Inferred from mutant phenotype
27534431 GOA
involved in Golgi to plasma membrane protein transport IMP
IMP: Inferred from mutant phenotype
15837803 GOA
involved in cellular response to unfolded protein IMP
IMP: Inferred from mutant phenotype
27534431 GOA
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
21617041 GOA
involved in negative regulation of receptor recycling IMP
IMP: Inferred from mutant phenotype
22854040 GOA
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
21617041 GOA
involved in positive regulation of xenophagy IMP
IMP: Inferred from mutant phenotype
21617041 GOA
involved in protein localization to Golgi apparatus IMP
IMP: Inferred from mutant phenotype
15837803 GOA
involved in type 2 mitophagy IMP
IMP: Inferred from mutant phenotype
25294927 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15837803 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
20174559 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OPTN Protein Structure

NEMO

NEMO: NF-kappa-B essential modulator NEMO (38 - 104)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
Protein Preferred Names Protein Names

optineurin

E3-14.7K-interacting protein

OPTN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra OPTN Q96CV9 WDFY3 Homo sapiens Q8IZQ1-2
Validated Y2H
32814053
Intra OPTN Q96CV9 WDFY3 Homo sapiens Q8IZQ1-2
Y2H Array
32814053
Intra OPTN Q96CV9 WDFY3 Homo sapiens Q8IZQ1-2
Y2H Pooling
32814053
Intra OPTN Q96CV9 RNF220 Homo sapiens Q9BWG1
Y2H Array
32814053
Intra OPTN Q96CV9 RNF220 Homo sapiens Q9BWG1
Validated Y2H
32814053
Intra OPTN Q96CV9 RNF220 Homo sapiens Q9BWG1
Y2H Pooling
32814053
Intra OPTN Q96CV9 AP3B1 Homo sapiens O00203
Y2H Array
32814053
Intra OPTN Q96CV9 AP3B1 Homo sapiens O00203
Validated Y2H
32814053
Intra OPTN Q96CV9 AP3B1 Homo sapiens O00203
Y2H Pooling
32814053
Intra OPTN Q96CV9 TBC1D15 Homo sapiens Q8TC07
Y2H Prey Pooling
25416956
Intra OPTN Q96CV9 TBC1D15 Homo sapiens Q8TC07
Y2H Array
25416956
Intra OPTN Q96CV9 CEP250 Homo sapiens Q9BV73
Validated Y2H
32814053
Intra OPTN Q96CV9 CEP250 Homo sapiens Q9BV73
Y2H Array
32814053
Intra OPTN Q96CV9 CEP250 Homo sapiens Q9BV73
Y2H Pooling
32814053
Intra OPTN Q96CV9 CCDC13 Homo sapiens Q8IYE1
Y2H Array
32296183
Intra OPTN Q96CV9 CCDC13 Homo sapiens Q8IYE1
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 ZMYM4 Homo sapiens Q5VZL5-4
Y2H Pooling
32814053
Intra OPTN Q96CV9 ZMYM4 Homo sapiens Q5VZL5-4
Validated Y2H
32814053
Intra OPTN Q96CV9 ZMYM4 Homo sapiens Q5VZL5-4
Y2H Array
32814053
Intra OPTN Q96CV9 MECP2 Homo sapiens P51608
Validated Y2H
32814053
Intra OPTN Q96CV9 MECP2 Homo sapiens P51608
Y2H Array
32814053
Intra OPTN Q96CV9 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
Intra OPTN Q96CV9 ZNF444 Homo sapiens Q8N0Y2-2
Validated Y2H
32814053
Intra OPTN Q96CV9 ZNF444 Homo sapiens Q8N0Y2-2
Y2H Array
32814053
Intra OPTN Q96CV9 ZNF444 Homo sapiens Q8N0Y2-2
Y2H Pooling
32814053
Intra OPTN Q96CV9 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra OPTN Q96CV9 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 JADE1 Homo sapiens Q6IE81-3
Validated Y2H
32814053
Intra OPTN Q96CV9 JADE1 Homo sapiens Q6IE81-3
Y2H Pooling
32814053
Intra OPTN Q96CV9 JADE1 Homo sapiens Q6IE81-3
Y2H Array
32814053
Intra OPTN Q96CV9 P3H3 Homo sapiens Q8IVL6-2
Y2H Array
32814053
Intra OPTN Q96CV9 P3H3 Homo sapiens Q8IVL6-2
Y2H Pooling
32814053
Intra OPTN Q96CV9 P3H3 Homo sapiens Q8IVL6-2
Validated Y2H
32814053
Intra OPTN Q96CV9 MYEOV Homo sapiens Q96EZ4
Validated Y2H
32814053
Intra OPTN Q96CV9 MYEOV Homo sapiens Q96EZ4
Y2H Array
32814053
Intra OPTN Q96CV9 MYEOV Homo sapiens Q96EZ4
Y2H Pooling
32814053
Intra OPTN Q96CV9 AIMP1 Homo sapiens Q12904-2
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 AIMP1 Homo sapiens Q12904-2
Y2H Array
32296183
Intra OPTN Q96CV9 KIAA0825 Homo sapiens Q8IV33
Y2H Pooling
32814053
Intra OPTN Q96CV9 KIAA0825 Homo sapiens Q8IV33
Validated Y2H
32814053
Intra OPTN Q96CV9 KIAA0825 Homo sapiens Q8IV33
Y2H Array
32814053
Intra OPTN Q96CV9 ZYG11B Homo sapiens Q9C0D3
Validated Y2H
32814053
Intra OPTN Q96CV9 ZYG11B Homo sapiens Q9C0D3
Y2H Pooling
32814053
Intra OPTN Q96CV9 ZYG11B Homo sapiens Q9C0D3
Y2H Array
32814053
Intra OPTN Q96CV9 CPN1 Homo sapiens P15169
Y2H Array
32814053
Intra OPTN Q96CV9 CPN1 Homo sapiens P15169
Y2H Pooling
32814053
Intra OPTN Q96CV9 CPN1 Homo sapiens P15169
Validated Y2H
32814053
Intra OPTN Q96CV9 DPP9 Homo sapiens Q86TI2-2
Validated Y2H
32814053
Intra OPTN Q96CV9 DPP9 Homo sapiens Q86TI2-2
Y2H Array
32814053
Intra OPTN Q96CV9 DPP9 Homo sapiens Q86TI2-2
Y2H Pooling
32814053
Intra OPTN Q96CV9 RNF111 Homo sapiens Q6ZNA4-2
Y2H Pooling
32814053
Intra OPTN Q96CV9 RNF111 Homo sapiens Q6ZNA4-2
Validated Y2H
32814053
Intra OPTN Q96CV9 RNF111 Homo sapiens Q6ZNA4-2
Y2H Array
32814053
Intra OPTN Q96CV9 UBE2A Homo sapiens P49459
Y2H Array
32814053
Intra OPTN Q96CV9 UBE2A Homo sapiens P49459
Y2H Pooling
32814053
Intra OPTN Q96CV9 UBE2A Homo sapiens P49459
Validated Y2H
32814053
Intra OPTN Q96CV9 LNX2 Homo sapiens Q8N448
Y2H Array
31515488
Intra OPTN Q96CV9 LNX2 Homo sapiens Q8N448
Y2H Array
29892012
Intra OPTN Q96CV9 ZMYM6 Homo sapiens O95789
Anti Tag CoIP
33961781
Intra OPTN Q96CV9 HLA-DPB1 Homo sapiens A0A1C3PI11
Validated Y2H
32814053
Intra OPTN Q96CV9 HLA-DPB1 Homo sapiens A0A1C3PI11
Y2H Pooling
32814053
Intra OPTN Q96CV9 HLA-DPB1 Homo sapiens A0A1C3PI11
Y2H Array
32814053
Intra OPTN Q96CV9 THADA Homo sapiens Q6YHU6
Y2H Pooling
32814053
Intra OPTN Q96CV9 THADA Homo sapiens Q6YHU6
Validated Y2H
32814053
Intra OPTN Q96CV9 THADA Homo sapiens Q6YHU6
Y2H Array
32814053
Intra OPTN Q96CV9 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
25026213
Intra OPTN Q96CV9 SQSTM1 Homo sapiens Q13501
Anti Bait CoIP
25026213
Intra OPTN Q96CV9 HACE1 Homo sapiens Q8IYU2
Anti Tag CoIP
25026213
Intra OPTN Q96CV9 HACE1 Homo sapiens Q8IYU2
Anti Bait CoIP
25026213
Intra OPTN Q96CV9 HACE1 Homo sapiens Q8IYU2
IF
25026213
Intra OPTN Q96CV9 HACE1 Homo sapiens Q8IYU2
Y2H
25026213
Intra OPTN Q96CV9 HACE1 Homo sapiens Q8IYU2
Pull Down
25026213
Intra OPTN Q96CV9 RBM12 Homo sapiens Q9NTZ6
Validated Y2H
25910212
Intra OPTN Q96CV9 RBM12 Homo sapiens Q9NTZ6
Y2H Array
25910212
Intra OPTN Q96CV9 RBM12 Homo sapiens Q9NTZ6
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 RBM12 Homo sapiens Q9NTZ6
Anti Tag CoIP
33961781
Intra OPTN Q96CV9 RBM12 Homo sapiens Q9NTZ6
Y2H Bait-Prey Pool
25910212
Intra OPTN Q96CV9 RBM12 Homo sapiens Q9NTZ6
Y2H Array
32296183
Intra OPTN Q96CV9 TBK1 Homo sapiens Q9UHD2
Pull Down
25803835
Intra OPTN Q96CV9 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
18307994
Intra OPTN Q96CV9 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
21903422
Intra OPTN Q96CV9 TBK1 Homo sapiens Q9UHD2
Pull Down
18307994
Intra OPTN Q96CV9 TBK1 Homo sapiens Q9UHD2
BioID
34524948
Intra OPTN Q96CV9 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
25803835
Intra OPTN Q96CV9 TBK1 Homo sapiens Q9UHD2
Anti Bait CoIP
27086836
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Y2H Array
26871637
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
26871637
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Y2H
21988832
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Validated Y2H
25910212
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Y2H Array
31515488
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Y2H Bait-Prey Pool
25910212
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
SLC
25910212
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Y2H Array
25910212
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Validated Y2H
25416956
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 TNIP1 Homo sapiens Q15025
Validated Y2H
26871637
Intra OPTN Q96CV9 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32814053
Intra OPTN Q96CV9 SMARCD1 Homo sapiens Q96GM5
Y2H Pooling
32814053
Intra OPTN Q96CV9 SMARCD1 Homo sapiens Q96GM5
Y2H Array
32814053
Intra OPTN Q96CV9 PSMC2 Homo sapiens P35998
Validated Y2H
32814053
Intra OPTN Q96CV9 PSMC2 Homo sapiens P35998
Y2H Array
32814053
Intra OPTN Q96CV9 PSMC2 Homo sapiens P35998
Y2H Pooling
32814053
Intra OPTN Q96CV9 ACSS3 Homo sapiens Q9H6R3
Y2H Pooling
32814053
Intra OPTN Q96CV9 ACSS3 Homo sapiens Q9H6R3
Validated Y2H
32814053
Intra OPTN Q96CV9 ACSS3 Homo sapiens Q9H6R3
Y2H Array
32814053
Intra OPTN Q96CV9 THAP6 Homo sapiens Q8TBB0
Validated Y2H
32814053
Intra OPTN Q96CV9 THAP6 Homo sapiens Q8TBB0
Y2H Pooling
32814053
Intra OPTN Q96CV9 THAP6 Homo sapiens Q8TBB0
Y2H Array
32814053
Intra OPTN Q96CV9 CDC23 Homo sapiens Q9UJX2
Y2H Bait-Prey Pool
25910212
Intra OPTN Q96CV9 CDC23 Homo sapiens Q9UJX2
Validated Y2H
25910212
Intra OPTN Q96CV9 CDC23 Homo sapiens Q9UJX2
SLC
25910212
Intra OPTN Q96CV9 CDC23 Homo sapiens Q9UJX2
Y2H Array
25910212
Intra OPTN Q96CV9 CDC23 Homo sapiens Q9UJX2
Y2H
21516116
Intra OPTN Q96CV9 CDC23 Homo sapiens Q9UJX2
Y2H Array
25416956
Intra OPTN Q96CV9 STIM1 Homo sapiens Q13586
Y2H Pooling
32814053
Intra OPTN Q96CV9 STIM1 Homo sapiens Q13586
Validated Y2H
32814053
Intra OPTN Q96CV9 STIM1 Homo sapiens Q13586
Y2H Array
32814053
Intra OPTN Q96CV9 HTT Homo sapiens P42858
Y2H Prey Pooling
23275563
Intra OPTN Q96CV9 DUS3L Homo sapiens Q96G46
Validated Y2H
32814053
Intra OPTN Q96CV9 DUS3L Homo sapiens Q96G46
Y2H Array
32814053
Intra OPTN Q96CV9 DUS3L Homo sapiens Q96G46
Y2H Pooling
32814053
Intra OPTN Q96CV9 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra OPTN Q96CV9 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 MPP1 Homo sapiens Q00013
Anti Tag CoIP
21903422
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
31515488
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
26871637
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
25416956
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
25910212
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
26871637
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
25416956
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
25416956
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
25910212
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
26871637
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Bait-Prey Pool
25910212
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
32296183
Intra OPTN Q96CV9 WASHC3 Homo sapiens Q9Y3C0
Y2H Pooling
16189514
Intra OPTN Q96CV9 TBC1D17 Homo sapiens Q9HA65
Confocal
22854040
Intra OPTN Q96CV9 TBC1D17 Homo sapiens Q9HA65
Anti Tag CoIP
22854040
Intra OPTN Q96CV9 TBC1D17 Homo sapiens Q9HA65
Y2H
22854040
Intra OPTN Q96CV9 TBC1D17 Homo sapiens Q9HA65
Y2H Pooling
16189514
Intra OPTN Q96CV9 TBC1D17 Homo sapiens Q9HA65
Anti Bait CoIP
22854040
Intra OPTN Q96CV9 RAB8A Homo sapiens P61006
Confocal
22854040
Intra OPTN Q96CV9 RAB8A Homo sapiens P61006
BiFC
20388642
Intra OPTN Q96CV9 RAB8A Homo sapiens P61006
Y2H
22854040
Intra OPTN Q96CV9 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
Intra OPTN Q96CV9 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
Intra OPTN Q96CV9 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 ZNF329 Homo sapiens Q86UD4
Y2H Array
25416956
Intra OPTN Q96CV9 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra OPTN Q96CV9 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
25416956
Intra OPTN Q96CV9 LITAF Homo sapiens Q99732
Validated Y2H
32814053
Intra OPTN Q96CV9 LITAF Homo sapiens Q99732
Y2H Array
32814053
Intra OPTN Q96CV9 LITAF Homo sapiens Q99732
Y2H Pooling
32814053
Intra OPTN Q96CV9 MGAT4B Homo sapiens Q9UQ53
Y2H Array
32814053
Intra OPTN Q96CV9 MGAT4B Homo sapiens Q9UQ53
Validated Y2H
32814053
Intra OPTN Q96CV9 MGAT4B Homo sapiens Q9UQ53
Y2H Pooling
32814053
Intra OPTN Q96CV9 MKNK1 Homo sapiens Q9BUB5
Y2H Pooling
32814053
Intra OPTN Q96CV9 MKNK1 Homo sapiens Q9BUB5
Validated Y2H
32814053
Intra OPTN Q96CV9 MKNK1 Homo sapiens Q9BUB5
Y2H Array
32814053
Intra OPTN Q96CV9 FXR2 Homo sapiens P51116
Y2H Array
32814053
Intra OPTN Q96CV9 FXR2 Homo sapiens P51116
Y2H Pooling
32814053
Intra OPTN Q96CV9 FXR2 Homo sapiens P51116
Validated Y2H
32814053
Intra OPTN Q96CV9 BEGAIN Homo sapiens Q9BUH8
Y2H Array
32814053
Intra OPTN Q96CV9 BEGAIN Homo sapiens Q9BUH8
Y2H Pooling
32814053
Intra OPTN Q96CV9 BEGAIN Homo sapiens Q9BUH8
Validated Y2H
32814053
Intra OPTN Q96CV9 ASMTL Homo sapiens O95671
Validated Y2H
32814053
Intra OPTN Q96CV9 ASMTL Homo sapiens O95671
Y2H Array
32814053
Intra OPTN Q96CV9 ASMTL Homo sapiens O95671
Y2H Pooling
32814053
Intra OPTN Q96CV9 ZNF426 Homo sapiens Q9BUY5
Validated Y2H
32296183
Intra OPTN Q96CV9 ZNF426 Homo sapiens Q9BUY5
Y2H Array
32296183
Intra OPTN Q96CV9 ZNF426 Homo sapiens Q9BUY5
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 LPXN Homo sapiens O60711
Y2H Array
32814053
Intra OPTN Q96CV9 LPXN Homo sapiens O60711
Validated Y2H
32814053
Intra OPTN Q96CV9 LPXN Homo sapiens O60711
Y2H Pooling
32814053
Intra OPTN Q96CV9 ZNF670 Homo sapiens Q9BS34
Y2H Array
25416956
Intra OPTN Q96CV9 ZNF670 Homo sapiens Q9BS34
Validated Y2H
32296183
Intra OPTN Q96CV9 H3C13 Homo sapiens Q71DI3
Y2H Pooling
32814053
Intra OPTN Q96CV9 H3C13 Homo sapiens Q71DI3
Validated Y2H
32814053
Intra OPTN Q96CV9 H3C13 Homo sapiens Q71DI3
Y2H Array
32814053
Intra OPTN Q96CV9 MMAB Homo sapiens Q96EY8
Y2H Pooling
32814053
Intra OPTN Q96CV9 MMAB Homo sapiens Q96EY8
Validated Y2H
32814053
Intra OPTN Q96CV9 MMAB Homo sapiens Q96EY8
Y2H Array
32814053
Intra OPTN Q96CV9 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra OPTN Q96CV9 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra OPTN Q96CV9 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra OPTN Q96CV9 ZNF398 Homo sapiens Q8TD17
Y2H Prey Pooling
25416956
Intra OPTN Q96CV9 ZNF398 Homo sapiens Q8TD17
Validated Y2H
25416956
Intra OPTN Q96CV9 TUT7 Homo sapiens Q5VYS8-5
Validated Y2H
32814053
Intra OPTN Q96CV9 TUT7 Homo sapiens Q5VYS8-5
Y2H Array
32814053
Intra OPTN Q96CV9 TUT7 Homo sapiens Q5VYS8-5
Y2H Pooling
32814053
Intra OPTN Q96CV9 ZNF597 Homo sapiens Q96LX8
Y2H Array
32814053
Intra OPTN Q96CV9 ZNF597 Homo sapiens Q96LX8
Validated Y2H
32814053
Intra OPTN Q96CV9 ZNF597 Homo sapiens Q96LX8
Y2H Pooling
32814053
Intra OPTN Q96CV9 QKI Homo sapiens Q96PU8
Y2H Pooling
32814053
Intra OPTN Q96CV9 QKI Homo sapiens Q96PU8
Validated Y2H
32814053
Intra OPTN Q96CV9 QKI Homo sapiens Q96PU8
Y2H Array
32814053
Intra OPTN Q96CV9 NRL Homo sapiens P54845-1
Anti Tag CoIP
23956131
Intra OPTN Q96CV9 NRL Homo sapiens P54845-1
IF
23956131
Cross OPTN Q96CV9 Q99IB8-PRO_0000045599 Hepatitis C virus Q99IB8-PRO_0000045599
Y2H
24136289
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary

Amyotrophic Lateral Sclerosis 12 With Or Without Frontotemporal Dementia

ALS12

Glaucoma, Normal Tension

Low Tension Glaucoma

Glaucoma, Normal Tension, Susceptibility To

Normal Tension Glaucoma

Ntg

Glaucoma, Normal Pressure

NPG

Glaucoma, Normal Pressure, Susceptibility To

Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]

Amyotrophic Lateral Sclerosis Type 12

Amyotrophic Lateral Sclerosis 12

Als12

Sclerosis, Lateral, Amyotrophic, Type Type 12

Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Open-Angle Glaucoma

Glaucoma Simplex

Pigmentary Glaucoma

Wide-Angle Glaucoma

Glaucoma, Open-Angle

Open Angle Glaucoma

Glaucoma Open-Angle

Chronic Simple Glaucoma

Coag - [Chronic Open-Angle Glaucoma]

Csg - [Chronic Simple Glaucoma]

Poag - [Primary Open-Angle Glaucoma]

Oag - [Open-Angle Glaucoma]

Chronic Glaucoma

Chronic Open Angle Glaucoma

Simple Glaucoma

Chronic Noncongestive Glaucoma

Ltg - [Low Tension Glaucoma]

Noncongestive Glaucoma

Nonobstructive Glaucoma

Normal Pressure Glaucoma

Primary Low Tension Glaucoma

Low-Tension Glaucoma

Residual Stage Low Tension Glaucoma

Open Cleft Glaucoma

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Intraocular Pressure Quantitative Trait Locus

Glaucoma

IOPQTL

Glaucoma, Susceptibility To

Postinfectious Glaucoma

Glaucoma With Ocular Inflammation

Glaucoma Secondary To Eye Inflammation

Traumatic Glaucoma

Glaucoma With Concussion Of Globe

Glaucoma Due To Ocular Trauma

Glaucoma Associated With Ocular Trauma

Glaucoma Secondary To Drugs

Glaucoma 1, Open Angle, A

GLC1A

Joag1

Glaucoma, Primary Open Angle, Juvenile-Onset, 1

Glaucoma 1a, Primary Open Angle

Primary Open Angle Glaucoma Juvenile Onset 1

Glaucoma Hereditary, Juvenile

Juvenile-Onset Primary Open Angle Glaucoma 1

Primary Open Angle Glaucoma 1a

Glaucoma, Open Angle, Type 1a

Glaucoma 3, Primary Congenital, A

Buphthalmos

Glaucoma, Congenital

Congenital Glaucoma

Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, Or Adult Onset

GLC3A

Glc3

Buphthalmia

Primary Congenital Glaucoma

Glaucoma, Primary Open Angle, Juvenile-Onset

Simple Buphthalmos

Buphthalmus

Glaucoma, Primary Open Angle, Adult-Onset

Primary Congenital Glaucoma 3a

Primary Infantile Glaucoma Type 3a

Glaucoma 3a, Primary Congenital

Glaucoma, Congenital, Primary, Type 3a

Hydrophthalmos

Cystic Eyeball

Ocular Hypertension

Hypertension, Ocular

Intraocular Pressure Increase

Oh - [Ocular Hypertension]

Oht - [Ocular Hypertension]

Optic Nerve Disease

Optic Neuropathy

Disorder Of The Second Nerve

Optic Nerve Disorder

Optic Nerve

Abnormality Of The Optic Nerve

Optic Nerve Disorders

Neuropathy, Optic

Disorder Of The Optic Nerve

Lateral Sclerosis

Primary Lateral Sclerosis

Adult-Onset Primary Lateral Sclerosis

Adult-Onset Pls

Motor Neuron Disease

Pls

Pls - [Primary Lateral Sclerosis]

Lateral Spinal Sclerosis

Lateral Complete Paralysis

Lateral Incomplete Paralysis

Lateral Paralysis

Dementia

Dementias

Presenile Dementia

Alzheimer Type Dementia

Alzheimer Sclerosis

Alzheimer Disease Dementia

Alzheimer Dementia

Primary Degenerative Alzheimer Type Dementia

End Stage Alzheimer'S Dementia

Alzheimer'S Type Atypical Dementia

Alzheimer Type Presenile Dementia

Early Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 2

Dementia In Alzheimer Disease With Early Onset

Early Onset Alzheimer Type Dementia, Uncomplicated

Primary Degenerative Alzheimer Type Dementia, Early Onset

Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

Alzheimer Disease Dementia With Early Onset

Presenile Sclerosis

Presenile Brain Sclerosis

Presenile Alzheimer Brain Sclerosis

Late Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 1

Dementia In Alzheimer Disease With Late Onset

Primary Degenerative Alzheimer Type Dementia, Late Onset

Sdat - [Senile Dementia, Alzheimer Type]

Alzheimer Disease Dementia With Late Onset

Late Onset Alzheimer Brain Sclerosis

Senile Alzheimer Brain Disease

Senile Alzheimer Brain Sclerosis

Senile Primary Degenerative Alzheimer Type Dementia

Senile Dementia Of The Alzheimer Type

Arteriosclerotic Dementia

Strategic-Infarct Dementia

Post Stroke Dementia

Vascular Cognitive Impairment

Vascular Dementia

Dementia Of The Lewy Body Type

Dementia With Lewy Bodies

Sdlt - [Senile Dementia Of The Lewy Body Type]

Senile Dementia Of The Lewy Body Type

Alcohol-Related Dementia

Alcoholic Dementia Nos

Alcohol-Induced Dementia

Alcoholic Brain Syndrome

Chronic Alcoholic Brain Syndrome

Alcohol Dementia

Late Onset Alcoholic Psychosis

Residual And Late-Onset Alcohol-Induced Psychotic Disorder

Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

Late-Onset Psychoactive Substance-Induced Psychotic Disorder

Inhalant Dementia

Volatile Solvents Dementia

Dementia In Paralysis Agitans

Pdd - [Parkinson Disease Dementia]

Dementia Syndrome Of Parkinson Disease

Dementia In Parkinson Disease

Parkinson Related Dementia

Dementia In Huntington Chorea

Hiv - [Human Immunodeficiency Virus] Dementia

Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

Aids Related Dementia

Dementia Due To Niacin Deficiency

Aphasia
Neuropathy

Peripheral Neuropathy

Peripheral Neuropathies

Paget'S Disease Of Bone

Osteitis Deformans

Paget Disease Of Bone

Osseous Paget'S Disease

Paget Disease Of Bone, Familial

Bone Paget Disease

Familial Paget'S Disease Of Bone

Paget'S Bone Disease

Familial Paget Disease Of Bone

Paget Disease, Bone

Pdb

Pagets Bone Disease

Juvenile Glaucoma

Glaucoma Of Childhood

Hydrophthalmos

Spinocerebellar Ataxia 2

Spinocerebellar Ataxia Type 2

SCA2

Amyotrophic Lateral Sclerosis 13

Spinocerebellar Degeneration With Slow Eye Movements

SDSEM

Spinocerebellar Atrophy Ii

Olivopontocerebellar Atrophy Ii

Opca2

Cerebellar Degeneration With Slow Eye Movements

Wadia-Swami Syndrome

Amyotrophic Lateral Sclerosis Type 13

ALS13

Olivopontocerebellar Atrophy Holguin Type

Spinocerebellar Ataxia Cuban Type

Olivopontocerebellar Atrophy, Holguin Type

Spinocerebellar Ataxia, Cuban Type

Amyotrophic Lateral Sclerosis, Susceptibility To, 13

Olivopontocerebellar Atrophy 2

Sca 2

Spinocerebellar Ataxia With Slow Eye Movements

Spinocerebellar Atrophy 2

Wadia Swami Syndrome

Opca Ii

Spinocerebellar Ataxia-2

Ataxia, Spinocerebellar, Type 2

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia

Primary Congenital Glaucoma
Amyotrophic Lateral Sclerosis Type 15

Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia

Als15

Amyotrophic Lateral Sclerosis 15

Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Amyotrophic Lateral Sclerosis Type 14

Als14

Amyotrophic Lateral Sclerosis 14

Amyotrophic Lateral Sclerosis, With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 14 With Or Without Frontotemporal Dementia

Acute Closed-Angle Glaucoma

Acute Angle-Closure Glaucoma

Multisystem Proteinopathy
Phacogenic Glaucoma
Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis Type 10

ALS10

Amyotrophic Lateral Sclerosis 10, With Or Without Ftd

Frontotemporal Lobar Degeneration, Tardbp-Related

Amyotrophic Lateral Sclerosis 10

Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia

Tardbp-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions

Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia And With Tdp43 Inclusions

Sclerosis, Lateral, Amyotrophic, Type Type 10

Steroid-Induced Glaucoma

Corticosteroid-Induced Glaucoma

Amyotrophic Lateral Sclerosis 11

Amyotrophic Lateral Sclerosis Type 11

ALS11

Sclerosis, Lateral, Amyotrophic, Type Type 11

Primary Angle-Closure Glaucoma

Primary Angle Closure Glaucoma

Angle Closure Glaucoma

Acg - [Angle Closure Glaucoma]

Angle-Closure Glaucoma

Closed Angle Glaucoma

Acute Glaucoma

Prodromal Angle Closure Glaucoma

Amyotrophic Lateral Sclerosis 16, Juvenile

Amyotrophic Lateral Sclerosis Type 16

ALS16

Amyotrophic Lateral Sclerosis 16

Sclerosis, Lateral, Amyotrophic, Type 16, Juvenile

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

Pagetoid Amyotrophic Lateral Sclerosis

Pagetoid Neuroskeletal Syndrome

Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

Multisystem Proteinopathy

Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

Lower Motor Neuron Degeneration With Paget-Like Bone Disease

Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Progressive Muscular Atrophy

Progressive Spinal Muscular Atrophy

Pure Progressive Muscular Atrophy

Pma

Hereditary Spinal Muscle Atrophy

Pma - [Progressive Muscular Atrophy]

Progressive Muscle Atrophy

Progressive Spinal Muscle Atrophy

Duchenne-Aran Atrophy

Duchenne-Aran Muscle Atrophy

Hereditary Sma - [Spinal Muscle Atrophy]

Amyotrophic Lateral Sclerosis 8

Amyotrophic Lateral Sclerosis Type 8

ALS8

Sclerosis, Lateral, Amyotrophic, Type Type 8

Mammary Paget'S Disease

Paget'S Disease

Mammary Paget Disease

Paget'S Disease Of The Breast

Paget Disease Of The Breast

Paget'S Disease Of The Nipple

Paget'S Disease, Mammary

Paget Cell Neoplasm

Paget Disease Of The Nipple

Pagets Disease Mammary

Osteitis Deformans

Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive

Als6

Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia

Autosomal Recessive Amyotrophic Lateral Sclerosis 6

Sclerosis, Lateral, Amyotrophic, Type Type 6

Amyotrophic Lateral Sclerosis 6

Keratitis, Hereditary

Keratitis

Autosomal Dominant Keratitis

Hereditary Keratitis

Dominantly Inherited Keratitis

Keratitis Hereditary

KERH

Retinal Degeneration

Degeneration Of Retina

Cranial Nerve Disease

Cranial Nerve Disorder

Disorder Of Cranial Nerve

Cranial Nerve Diseases

Giant Axonal Neuropathy 2
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis

Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Leber Hereditary Optic Neuropathy, Modifier Of

Leber Optic Atrophy

Leber Hereditary Optic Neuropathy

LHON

Leber'S Hereditary Optic Neuropathy

Leber Optic Atrophy, Susceptibility To

Leber'S Optic Atrophy

LOAM

Loas

Leber'S Disease

Leber'S Optic Neuropathy

Optic Atrophy, Hereditary, Leber

Lhon, Modifier Of

Optic Atrophy, Leber Type

Hereditary Optic Neuroretinopathy

Leber Hereditary Optic Atrophy

Loa

Optic Atrophy Leber Type

Leber Hereditary Optic Neuropathy, Modifier

Leber Hereditary Optic Neuropathy Susceptibility

Modifier Of Leber Hereditary Optic Neuropathy

Lebers Hereditary Optic Neuropathy

Leber Congenital Amaurosis

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus OPTN VGNC VGNC:32442
Felis catus OPTN VGNC VGNC:63970
Macaca mulatta OPTN VGNC VGNC:75415
Canis familiaris OPTN VGNC VGNC:44136
Rattus norvegicus OPTN RGD RGD:628886
Mus musculus OPTN MGD MGI:1918898
Others OPTN NCBI