CEBPZ - CCAAT enhancer binding protein zeta Gene

Homo sapiens

Also known as CBF; CBF2; NOC1; HSP-CBF

Gene ID: 10153 | Gene type: protein coding

About CEBPZ

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,201,612-37,231,596 (from NCBI)

This gene has 3 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 27.1), adrenal (RPKM 18.8) and 25 other tissues.

Summary

This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. [provided by RefSeq, Nov 2020]

CEBPZ Products(1)

mRNA	Protein	Name
NM_005760.3	NP_005751.2	CCAAT/enhancer-binding protein zeta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables DNA binding	IDA IDA: Inferred from direct assay	11306579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21900206	GOA
enables transcription coactivator activity	IGI IGI: Inferred from genetic interaction	11306579	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	2247079	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11306579	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEBPZ Protein Structure

CBF

0
200
400
600
800
1000
1054 a.a.

Protein Preferred Names

Protein Names

CCAAT/enhancer-binding protein zeta

CCAAT-box-binding transcription factor

CEBPZ Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CEBPZ	Q03701	PRKRA	Homo sapiens	O75569	Y2H	21900206

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Opportunistic Bacterial Infectious Disease

Nocardiosis

Nocardia Infection	Nocardia Infections
Nocardia Infectious Disease	Lung Nocardiosis
Nocardiasis	Nocardiosis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02450	CEBPZ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CEBPZ	VGNC	VGNC:71082
Felis catus	CEBPZ	VGNC	VGNC:60741
Mus musculus	CEBPZ	MGD	MGI:109386
Canis familiaris	CEBPZ	VGNC	VGNC:39090
Rattus norvegicus	CEBPZ	RGD	RGD:1304994
Bos taurus	CEBPZ	VGNC	VGNC:27164

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