FARP1 - FERM, ARH/RhoGEF and pleckstrin domain protein 1 Gene

Homo sapiens

Also known as CDEP; GLCC1; PLEKHC2; PPP1R75; FARP1-IT1

Gene ID: 10160 | Gene type: protein coding

About FARP1

Cytogenetic location: 13q32.2 Genomic coordinates (GRCh38): 13:98,142,172-98,455,176 (from NCBI)

This gene has 42 transcripts (splice variants), 281 orthologues and 10 paralogues. Ubiquitous expression in kidney (RPKM 19.9), thyroid (RPKM 13.0) and 24 other tissues.

Summary

This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the Cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

FARP1 Products(3)

mRNA	Protein	Name
NM_001001715.4	NP_001001715.2	FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 2
NM_001286839.2	NP_001273768.1	FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 3
NM_005766.4	NP_005757.1	FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FARP1 Protein Structure

FERM_N

FERM_M

FERM_C

RhoGEF

0
200
400
600
800
1045 a.a.

Protein Preferred Names

Protein Names

FERM, ARHGEF and pleckstrin domain-containing protein 1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

FARP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FARP1	Q9Y4F1	PIH1D1	Homo sapiens	Q9NWS0	Y2H Array	32296183
Intra	FARP1	Q9Y4F1	PIH1D1	Homo sapiens	Q9NWS0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nystagmus 3, Congenital, Autosomal Dominant

NYS3	Congenital Nystagmus 3
Autosomal Dominant Congenital Nystagmus 3

Premature Ovarian Failure 18

POF18	Primary Ovarian Insufficiency 18
Ovarian Failure, Premature, Type 18

Pathologic Nystagmus

Nystagmus

Congenital Nystagmus

Nystagmus, Congenital

Nystagmus Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04746	FARP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FARP1	RGD	RGD:1305346
Macaca mulatta	FARP1	VGNC	VGNC:72614
Mus musculus	FARP1	MGD	MGI:2446173
Felis catus	FARP1	VGNC	VGNC:62149
Bos taurus	FARP1	VGNC	VGNC:28865
Canis familiaris	FARP1	VGNC	VGNC:40730

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