ANGPTL7 - angiopoietin like 7 Gene

Homo sapiens

Also known as AngX; CDT6; dJ647M16.1

Gene ID: 10218 | Gene type: protein coding

About ANGPTL7

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,189,355-11,195,981 (from NCBI)

This gene has 2 transcripts (splice variants), 316 orthologues and 25 paralogues. Broad expression in heart (RPKM 2.5), gall bladder (RPKM 2.2) and 15 other tissues.

Summary

Enables identical protein binding activity. Involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye and regulation of extracellular matrix organization. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

ANGPTL7 Products(1)

mRNA	Protein	Name
NM_021146.4	NP_066969.1	angiopoietin-related protein 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	11682471	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye	IMP IMP: Inferred from mutant phenotype	25622036	GOA
involved in regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	21199193	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	11682471	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

angiopoietin-related protein 7

angiopoietin-like factor (CDT6)

Recombinant ANGPTL7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7509	ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, His)	O43827 (Q27-P346)	≥95%
HY-P700852	ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, hFc)	O43827 (Q27-P346)	≥95%
HY-P700955	ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, His-Avi)	O43827 (Q27-P346)	≥95%

Related Diseases

Diseases

Alias

Steroid-Induced Glaucoma

Corticosteroid-Induced Glaucoma

Schnyder Corneal Dystrophy

Schnyder Crystalline Corneal Dystrophy	SCCD
Corneal Dystrophy, Crystalline, Of Schnyder	Corneal Dystrophy, Schnyder Type
Corneal Dystrophy Crystalline Of Schnyder	Crystalline Stromal Dystrophy
Hereditary Crystalline Stromal Dystrophy Of Schnyder	Scd
Corneal Dystrophy, Schnyder	Schnyder Crystalline Dystrophy Sine Crystals
Dystrophy, Corneal, Crystalline, Schnyder

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00696	ANGPTL7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ANGPTL7	VGNC	VGNC:25895
Canis familiaris	ANGPTL7	VGNC	VGNC:37863
Macaca mulatta	ANGPTL7	VGNC	VGNC:69683
Rattus norvegicus	ANGPTL7	RGD	RGD:7553363
Felis catus	ANGPTL7	VGNC	VGNC:59783
Mus musculus	ANGPTL7	MGD	MGI:3605801
Others	ANGPTL7	NCBI

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