MFSD10 - major facilitator superfamily domain containing 10 Gene

Homo sapiens

Also known as TETRAN; TETTRAN

Gene ID: 10227 | Gene type: protein coding

About MFSD10

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,930,567-2,934,825 (from NCBI)

This gene has 11 transcripts (splice variants), 571 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 36.8), spleen (RPKM 13.5) and 24 other tissues.

Summary

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

MFSD10 Products(4)

mRNA	Protein	Name
NM_001120.5	NP_001111.3	major facilitator superfamily domain-containing protein 10 isoform a
NM_001146069.2	NP_001139541.1	major facilitator superfamily domain-containing protein 10 isoform a
NM_001363679.2	NP_001350608.1	major facilitator superfamily domain-containing protein 10 isoform b
NM_001410703.1	NP_001397632.1	major facilitator superfamily domain-containing protein 10 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18638446	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within sodium-independent organic anion transport	IDA IDA: Inferred from direct assay	18638446	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	18638446	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MFSD10 Protein Structure

MFS_1

0
100
200
300
400
455 a.a.

Protein Preferred Names

Protein Names

major facilitator superfamily domain-containing protein 10

tetracycline transporter-like protein

MFSD10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MFSD10	Q14728	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	MFSD10	Q14728	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	MFSD10	Q14728	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	MFSD10	Q14728	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	MFSD10	Q14728	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	MFSD10	Q14728	PECAM1	Homo sapiens	P16284	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mahvash Disease

Gcgr-Related Hyperglucagonemia	MVAH
Alpha-Cell Hyperplasia With Glucagonemia	Nesidioblastosis, Alpha Cell Hyperplasia, Microglucagonoma, And Nonfunctioning Islet Cell Tumor
Nesidioblastosis Alpha Cell Hyperplasia Microglucagonoma And Nonfunctioning Islet Cell Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08388	MFSD10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MFSD10	VGNC	VGNC:63475
Canis familiaris	MFSD10	VGNC	VGNC:43196
Rattus norvegicus	MFSD10	RGD	RGD:1311900
Bos taurus	MFSD10	VGNC	VGNC:31432
Macaca mulatta	MFSD10	VGNC	VGNC:100247
Mus musculus	MFSD10	MGD	MGI:1915544

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