KCNMB2 - potassium calcium-activated channel subfamily M regulatory beta subunit 2 Gene

Homo sapiens

Gene ID: 10242 | Gene type: protein coding

About KCNMB2

Cytogenetic location: 3q26.32 Genomic coordinates (GRCh38): 3:178,536,436-178,844,429 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues and 3 paralogues. Biased expression in ovary (RPKM 5.5), adrenal (RPKM 2.4) and 8 other tissues.

Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]

KCNMB2 Products(3)

mRNA	Protein	Name
NM_001278911.2	NP_001265840.1	calcium-activated potassium channel subunit beta-2
NM_005832.5	NP_005823.1	calcium-activated potassium channel subunit beta-2
NM_181361.3	NP_852006.1	calcium-activated potassium channel subunit beta-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-activated potassium channel activity	IDA IDA: Inferred from direct assay	10692449	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in action potential	IDA IDA: Inferred from direct assay	10692449	GOA
involved in detection of calcium ion	IDA IDA: Inferred from direct assay	10692449	GOA
involved in neuronal action potential	IDA IDA: Inferred from direct assay	10692449	GOA
involved in potassium ion transport	IDA IDA: Inferred from direct assay	10692449	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	10692449	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	10692449	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNMB2 Protein Structure

KcnmB2_inactiv

CaKB

0
100
200
235 a.a.

Protein Preferred Names

Protein Names

calcium-activated potassium channel subunit beta-2

BK channel beta subunit 2

KCNMB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KCNMB2	Q9Y691	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KCNMB2	Q9Y691	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KCNMB2	Q9Y691	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07166	KCNMB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KCNMB2	VGNC	VGNC:102763
Rattus norvegicus	KCNMB2	RGD	RGD:631398
Canis familiaris	KCNMB2	VGNC	VGNC:54103
Mus musculus	KCNMB2	MGD	MGI:1919663
Macaca mulatta	KCNMB2	VGNC	VGNC:84158

Name
Email *

	Sorry, but the email address you supplied was invalid.