MC1R - melanocortin 1 receptor Gene

Rattus norvegicus

Gene ID: 102552838 | Gene type: protein coding

About MC1R

Primary_assembly 19: 51,453,239-51,454,192 forward strand.mRatBN7.2:CM026992.1

This gene has 1 transcript (splice variant), 156 orthologues, 18 paralogues and is associated with 25 phenotypes.

Summary

Enables hormone binding activity and Melanocortin Receptor activity. Involved in positive regulation of feeding behavior. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

MC1R Products(1)

mRNA	Protein	Name
NM_001401091.1	NP_001388020.1	melanocortin 1 receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone binding	IMP IMP: Inferred from mutant phenotype	16454799	RGD
enables melanocortin receptor activity	IMP IMP: Inferred from mutant phenotype	16454799	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	16257393	RGD
involved in regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	19340414	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MC1R Protein Structure

7tm_GPCRs

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

melanocortin 1 receptor

melanocyte-stimulating hormone receptor

alpha melanocyte stimulating hormone receptor

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2466	Melanotan I	Agonist	99.75%	Unkown
HY-N2466A	Melanotan I acetate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147301	Resomelagon	Agonist	99.63%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115644	BMS-470539 dihydrochloride	Agonist	99.95%	Unkown
HY-P0097A	Nonapeptide-1 acetate salt	Antagonist	98.70%	Unkown
HY-P1545A	ACTH (1-17) (TFA)	Agonist	99.19%	Unkown
HY-P0097	Nonapeptide-1	Antagonist	99.04%	Unkown
HY-P2336A	CCZ01048 TFA		98.48%	Unkown
HY-P99004	hMC1R agonist 1	Antagonist	/	Unkown
HY-P1726A	MSG606 TFA	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MC1R	NCBI	NCBI:4157
Mus musculus	MC1R	NCBI	NCBI:17199

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