2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. CCZ01048 TFA

CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CCZ01048 TFA Chemical Structure

CCZ01048 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 480 In-stock
5 mg USD 1380 In-stock
10 mg USD 2150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of CCZ01048 TFA:

CCZ01048 TFA Related Antibodies

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MC1R MC3R MC2R MC4R MC5R

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Description

CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma[1].

IC50 & Target

MC1R

 

In Vivo

The cationic Pip linker to Nle-CycMSHhex, CCZ01048, not only improves tumor uptake, but also generates high tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1622.75

Formula

C73H106F3N21O18
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (61.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6162 mL 3.0812 mL 6.1624 mL
5 mM 0.1232 mL 0.6162 mL 1.2325 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6162 mL 3.0812 mL 6.1624 mL 15.4059 mL
5 mM 0.1232 mL 0.6162 mL 1.2325 mL 3.0812 mL
10 mM 0.0616 mL 0.3081 mL 0.6162 mL 1.5406 mL
15 mM 0.0411 mL 0.2054 mL 0.4108 mL 1.0271 mL
20 mM 0.0308 mL 0.1541 mL 0.3081 mL 0.7703 mL
25 mM 0.0246 mL 0.1232 mL 0.2465 mL 0.6162 mL
30 mM 0.0205 mL 0.1027 mL 0.2054 mL 0.5135 mL
40 mM 0.0154 mL 0.0770 mL 0.1541 mL 0.3851 mL
50 mM 0.0123 mL 0.0616 mL 0.1232 mL 0.3081 mL
60 mM 0.0103 mL 0.0514 mL 0.1027 mL 0.2568 mL
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CCZ01048 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCZ01048CCZ 01048CCZ-01048Melanocortin ReceptorMC ReceptormalignantmelanomatumorB16F10cellsPETimagingInhibitorinhibitorinhibit

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