CCNO - cyclin O Gene

Homo sapiens

Also known as CCNU; UDG2; CILD29

Gene ID: 10309 | Gene type: protein coding

About CCNO

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,231,152-55,233,608 (from NCBI)

This gene has 2 transcripts (splice variants), 231 orthologues, 18 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 3.3), stomach (RPKM 2.3) and 16 other tissues.

Summary

This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

CCNO Products(1)

mRNA	Protein	Name
NM_021147.5	NP_066970.3	cyclin-O

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	24747639	GOA
involved in mitotic cell cycle	IDA IDA: Inferred from direct assay	8419333	GOA
involved in multi-ciliated epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	24747639	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24747639	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	28860486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNO Protein Structure

Cyclin_N

Cyclin_C

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

cyclin-O

cyclin U

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 29

Primary Ciliary Dyskinesia 29	CILD29
Ciliary Dyskinesia, Primary, 29, Without Situs Inversus	Primary Ciliary Dyskinesia 29 Without Situs Inversus
Primary Ciliary Dyskinesia Without Situs Inversus	Dyskinesia, Ciliary, Primary, Type 29

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Bronchiectasis

Polynesian Bronchiectasis	Kartagener Syndrome
Bronchiectasis Nos

Chromosome 17q12 Duplication Syndrome

17q12 Microduplication Syndrome	Trisomy 17q12
17q12 Duplication	17q12 Microduplication
Dup(17)(Q12)	Recurrent Duplication Of 17q12
17q12 Duplication Syndrome	17q12 Recurrent Duplication

Chronic Rhinitis

Rhinitis - Chronic	Chronic Rhinitis Nos
Rhinitis	Rhinitis Nos

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Otorrhea

Discharging Ear

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Kartagener Syndrome

Kartagener'S Syndrome

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02138	CCNO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CCNO	VGNC	VGNC:52117
Bos taurus	CCNO	VGNC	VGNC:26977
Rattus norvegicus	CCNO	RGD	RGD:1565217
Macaca mulatta	CCNO	VGNC	VGNC:70824
Mus musculus	CCNO	MGD	MGI:2145534
Felis catus	CCNO	VGNC	VGNC:60567
Others	CCNO	NCBI

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