CRISP3 - cysteine rich secretory protein 3 Gene

Homo sapiens

Also known as Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3

Gene ID: 10321 | Gene type: protein coding

About CRISP3

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:49,727,376-49,744,388 (from NCBI)

This gene has 4 transcripts (splice variants), 165 orthologues and 13 paralogues. Biased expression in salivary gland (RPKM 504.8), bone marrow (RPKM 138.4) and 1 other tissue.

Summary

This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

CRISP3 Products(3)

mRNA	Protein	Name
NM_001190986.3	NP_001177915.1	cysteine-rich secretory protein 3 isoform 2
NM_001368123.1	NP_001355052.1	cysteine-rich secretory protein 3 isoform 3
NM_006061.4	NP_006052.2	cysteine-rich secretory protein 3 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	8601434	GOA
located in specific granule	IDA IDA: Inferred from direct assay	8601434	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRISP3 Protein Structure

CAP

Crisp

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

cysteine-rich secretory protein 3

specific granule protein (28 kDa)

Recombinant CRISP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70042	CRISP-3 Protein, Human (HEK293, His)	P54108 (N21-Y245)	≥95%

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03181	CRISP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CRISP3	RGD	RGD:619846
Mus musculus	CRISP3	MGD	MGI:102553
Others	CRISP3	NCBI

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