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  3. CRISP3 - cysteine rich secretory protein 3 Gene

CRISP3 - cysteine rich secretory protein 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3

Gene ID: 10321 | Gene type: protein coding

About CRISP3

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:49,727,376-49,744,388 (from NCBI)

This gene has 4 transcripts (splice variants), 165 orthologues and 13 paralogues. Biased expression in salivary gland (RPKM 504.8), bone marrow (RPKM 138.4) and 1 other tissue.

Summary

This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

CRISP3 Products(3)

mRNA Protein Name
NM_001190986.3 NP_001177915.1 cysteine-rich secretory protein 3 isoform 2
NM_001368123.1 NP_001355052.1 cysteine-rich secretory protein 3 isoform 3
NM_006061.4 NP_006052.2 cysteine-rich secretory protein 3 isoform 1 precursor

CRISP3 Protein Structure

CAP

CAP: Cysteine-rich secretory protein family (66 - 194)

Crisp

Crisp: Crisp (214 - 268)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

cysteine-rich secretory protein 3

specific granule protein (28 kDa)

Recombinant CRISP3 Proteins

Cat. No. Product Name Accession Purity
HY-P70042 CRISP-3 Protein, Human (HEK293, His) P54108 (N21-Y245) ≥95%

Related Diseases

Diseases Alias
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03181 CRISP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CRISP3 RGD RGD:619846
Mus musculus CRISP3 MGD MGI:102553
Others CRISP3 NCBI