NPM3 - nucleophosmin/nucleoplasmin 3 Gene

Homo sapiens

Also known as PORMIN; TMEM123

Gene ID: 10360 | Gene type: protein coding

About NPM3

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,781,325-101,783,446 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 11.1), appendix (RPKM 9.9) and 25 other tissues.

Summary

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]

NPM3 Products(1)

mRNA	Protein	Name
NM_006993.3	NP_008924.1	nucleoplasmin-3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22190034	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPM3 Protein Structure

Nucleoplasmin

0
100
178 a.a.

Protein Preferred Names

Protein Names

nucleoplasmin-3

nucleophosmin/nucleoplasmin family, member 3

NPM3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NPM3	O75607	UPRT	Homo sapiens	Q96BW1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Papillary Adenocarcinoma

Papillary Lung Adenocarcinoma

Papillary Adenocarcinoma Of The Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09492	NPM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NPM3	RGD	RGD:1565542
Felis catus	NPM3	VGNC	VGNC:97534
Mus musculus	NPM3	MGD	MGI:894653
Bos taurus	NPM3	VGNC	VGNC:32208
Macaca mulatta	NPM3	VGNC	VGNC:75385
Canis familiaris	NPM3	VGNC	VGNC:43923

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