SCML2 - Scm polycomb group protein like 2 Gene

Homo sapiens

Gene ID: 10389 | Gene type: protein coding

About SCML2

Cytogenetic location: Xp22.13 Genomic coordinates (GRCh38): X:18,239,313-18,355,118 (from NCBI)

This gene has 5 transcripts (splice variants), 279 orthologues and 18 paralogues. Broad expression in testis (RPKM 5.8), adrenal (RPKM 1.8) and 19 other tissues.

Summary

This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone Peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]

SCML2 Products(1)

mRNA	Protein	Name
NM_006089.3	NP_006080.1	sex comb on midleg-like protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24358021	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	10331946	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCML2 Protein Structure

MBT

SLED

SAM_1

0
200
400
600
700 a.a.

Protein Preferred Names

Protein Names

sex comb on midleg-like protein 2

sex comb on midleg like 2

SCML2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCML2	Q9UQR0	SRGAP2B	Homo sapiens	A0A286YEY3	Y2H Prey Pooling	32296183
Intra	SCML2	Q9UQR0	SRGAP2B	Homo sapiens	A0A286YEY3	Y2H Array	32296183
Intra	SCML2	Q9UQR0	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	SCML2	Q9UQR0	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	SCML2	Q9UQR0	CDK2	Homo sapiens	P24941	Anti Bait CoIP	24358021

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12517	SCML2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SCML2	VGNC	VGNC:76979
Canis familiaris	SCML2	VGNC	VGNC:45911
Bos taurus	SCML2	VGNC	VGNC:34341
Rattus norvegicus	SCML2	RGD	RGD:1564289
Felis catus	SCML2	VGNC	VGNC:82309
Mus musculus	SCML2	MGD	MGI:1340042

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