RNF4 - ring finger protein 4 Gene

Homo sapiens

Also known as SLX5; SNURF; RES4-26

Gene ID: 6047 | Gene type: protein coding

About RNF4

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,469,106-2,515,857 (from NCBI)

This gene has 21 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in lymph node (RPKM 20.6), testis (RPKM 19.4) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

RNF4 Products(3)

mRNA	Protein	Name
NM_001185009.3	NP_001171938.1	E3 ubiquitin-protein ligase RNF4 isoform 1
NM_001185010.3	NP_001171939.1	E3 ubiquitin-protein ligase RNF4 isoform 2
NM_002938.5	NP_002929.1	E3 ubiquitin-protein ligase RNF4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO polymer binding	IDA IDA: Inferred from direct assay	35013556	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	24714598	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10713105	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	35013556	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	35013556	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12885770	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	18408734	GOA
involved in regulation of kinetochore assembly	IMP IMP: Inferred from mutant phenotype	20212317	GOA
involved in regulation of spindle assembly	IMP IMP: Inferred from mutant phenotype	20212317	GOA
involved in response to arsenic-containing substance	IDA IDA: Inferred from direct assay	20943951	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with PML body	IDA IDA: Inferred from direct assay	20943951	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12885770	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12885770	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF4 Protein Structure

zf-RING_2

0
100
190 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF4

E3 ubiquitin ligase RNF4

RNF4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF4	P78317	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	RNF4	P78317	ZNF792	Homo sapiens	Q3KQV3	Validated Y2H	32296183
Intra	RNF4	P78317	LCE1B	Homo sapiens	Q5T7P3	Validated Y2H	32296183
Intra	RNF4	P78317	LCE2D	Homo sapiens	Q5TA82	Validated Y2H	32296183
Intra	RNF4	P78317	AKAP17A	Homo sapiens	Q02040	Validated Y2H	32296183
Intra	RNF4	P78317	LXN	Homo sapiens	Q9BS40	Validated Y2H	32296183
Intra	RNF4	P78317	ZNF696	Homo sapiens	Q9H7X3	Validated Y2H	32296183
Intra	RNF4	P78317	ZBTB34	Homo sapiens	Q8NCN2	Validated Y2H	32296183
Intra	RNF4	P78317	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	RNF4	P78317	CAMK2B	Homo sapiens	Q13554-3	Validated Y2H	32296183
Intra	RNF4	P78317	CAMK2D	Homo sapiens	Q13557-8	Validated Y2H	32296183
Intra	RNF4	P78317	LCE1D	Homo sapiens	Q5T752	Validated Y2H	32296183
Intra	RNF4	P78317	LCE1E	Homo sapiens	Q5T753	Validated Y2H	32296183
Intra	RNF4	P78317	LCE5A	Homo sapiens	Q5TCM9	Validated Y2H	32296183
Intra	RNF4	P78317	LCE1F	Homo sapiens	Q5T754	Validated Y2H	32296183
Intra	RNF4	P78317	LCE2C	Homo sapiens	Q5TA81	Validated Y2H	32296183
Intra	RNF4	P78317	LCE3B	Homo sapiens	Q5TA77	Validated Y2H	32296183
Intra	RNF4	P78317	RUNX1T1	Homo sapiens	Q06455-2	Validated Y2H	32296183
Intra	RNF4	P78317	ZNF319	Homo sapiens	Q9P2F9	Validated Y2H	32296183
Intra	RNF4	P78317	ZFP42	Homo sapiens	Q96MM3	Validated Y2H	32296183
Intra	RNF4	P78317	PRR20D	Homo sapiens	P86480	Validated Y2H	32296183
Intra	RNF4	P78317	UBTD2	Homo sapiens	Q8WUN7	Validated Y2H	32296183
Intra	RNF4	P78317	NKX3-1	Homo sapiens	Q99801	Validated Y2H	32296183
Intra	RNF4	P78317	ZNF275	Homo sapiens	Q9NSD4	Validated Y2H	32296183
Intra	RNF4	P78317	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	RNF4	P78317	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	RNF4	P78317	SCML2	Homo sapiens	Q9UQR0	Validated Y2H	32296183
Intra	RNF4	P78317	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	RNF4	P78317	TRPS1	Homo sapiens	Q9UHF7	Anti Tag CoIP	12885770
Intra	RNF4	P78317	TRPS1	Homo sapiens	Q9UHF7	Anti Bait CoIP	12885770
Intra	RNF4	P78317	DESI1	Homo sapiens	Q6ICB0	Validated Y2H	32296183
Intra	RNF4	P78317	BTBD3	Homo sapiens	Q9Y2F9	Validated Y2H	32296183
Intra	RNF4	P78317	DDX39B	Homo sapiens	Q13838	Validated Y2H	32296183
Intra	RNF4	P78317	CFL2	Homo sapiens	Q9Y281	Validated Y2H	32296183
Intra	RNF4	P78317	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	RNF4	P78317	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	RNF4	P78317	TRAF3	Homo sapiens	Q13114	Validated Y2H	32296183
Intra	RNF4	P78317	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	RNF4	P78317	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	RNF4	P78317	RHOXF2	Homo sapiens	Q9BQY4	Validated Y2H	32296183
Intra	RNF4	P78317	NMNAT1	Homo sapiens	Q9HAN9	Validated Y2H	32296183
Intra	RNF4	P78317	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	RNF4	P78317	MYD88	Homo sapiens	Q99836	Validated Y2H	32296183
Intra	RNF4	P78317	FADD	Homo sapiens	Q13158	Validated Y2H	32296183
Intra	RNF4	P78317	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	RNF4	P78317	ZBTB6	Homo sapiens	Q15916	Validated Y2H	32296183
Intra	RNF4	P78317	PHC1	Homo sapiens	P78364	Validated Y2H	32296183
Intra	RNF4	P78317	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	RNF4	P78317	SEPTIN3	Homo sapiens	Q9UH03	Validated Y2H	32296183
Intra	RNF4	P78317	KLHL12	Homo sapiens	Q53G59	Validated Y2H	32296183
Intra	RNF4	P78317	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	RNF4	P78317	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	RNF4	P78317	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	RNF4	P78317	ARK2N	Homo sapiens	Q96B23	Validated Y2H	32296183
Intra	RNF4	P78317	ZC3H10	Homo sapiens	Q96K80	Validated Y2H	32296183
Intra	RNF4	P78317	STX4	Homo sapiens	Q12846	Validated Y2H	32296183
Intra	RNF4	P78317	ZCCHC17	Homo sapiens	Q9NP64	Validated Y2H	32296183
Intra	RNF4	P78317	DAXX	Homo sapiens	Q9UER7	Validated Y2H	32296183
Intra	RNF4	P78317	BCL2L1	Homo sapiens	Q07817	Validated Y2H	32296183
Intra	RNF4	P78317	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32296183
Intra	RNF4	P78317	FAM118A	Homo sapiens	Q9NWS6	Validated Y2H	32296183
Intra	RNF4	P78317	BTBD1	Homo sapiens	Q9H0C5	Validated Y2H	32296183
Intra	RNF4	P78317	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-143346	CCW16		98.63%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RNF4	VGNC	VGNC:34065
Mus musculus	RNF4	MGD	MGI:1201691
Rattus norvegicus	RNF4	RGD	RGD:3583
Canis familiaris	RNF4	VGNC	VGNC:53203
Felis catus	RNF4	VGNC	VGNC:64702
Macaca mulatta	RNF4	VGNC	VGNC:76705
Others	RNF4	NCBI

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