SPON2 - spondin 2 Gene

Homo sapiens

Also known as DIL1; DIL-1; MINDIN; M-SPONDIN

Gene ID: 10417 | Gene type: protein coding

About SPON2

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,166,932-1,208,844 (from NCBI)

This gene has 22 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in prostate (RPKM 48.4), endometrium (RPKM 37.2) and 18 other tissues.

Summary

Predicted to enable antigen binding activity; lipopolysaccharide binding activity; and metal ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within several processes, including defense response to Other organism; opsonization; and positive regulation of cytokine production. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SPON2 Products(3)

mRNA	Protein	Name
NM_001128325.3	NP_001121797.2	spondin-2 precursor
NM_001199021.2	NP_001185950.2	spondin-2 precursor
NM_012445.4	NP_036577.2	spondin-2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPON2 Protein Structure

Spond_N

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

spondin-2

differentially expressed in cancerous and non-cancerous lung cells 1

SPON2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPON2	Q9BUD6	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	SPON2	Q9BUD6	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	SPON2	Q9BUD6	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	SPON2	Q9BUD6	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	SPON2	Q9BUD6	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	SPON2	Q9BUD6	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	SPON2	Q9BUD6	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	SPON2	Q9BUD6	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	SPON2	Q9BUD6	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	SPON2	Q9BUD6	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	SPON2	Q9BUD6	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	SPON2	Q9BUD6	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPON2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70142	Spondin-2/SPON2 Protein, Human (HEK293, His)	AAH02707.1 (Q27-V331)	≥95%

Related Diseases

Diseases

Alias

Pharyngitis

Acute Pharyngitis	Chronic Pharyngitis
Acute Sore Throat	Chronic Sore Throat
Persistent Sore Throat	Pharyngeal Diseases
Chronic Pharyn/Nasopharyngitis	Chronic Pharyngitis And Nasopharyngitis
Inflamed Throat	Pharyngeal Disease
Pharyngeal Disorder	Pharyngitis - Acute
Sore Throat - Chronic	Acute Pharyngitis Nos
Acute Sore Throat Nos	Acute Throat Inflammation
Infective Pharyngitis	Infection Of Pharynx
Acute Infective Pharyngitis	Acute Infective Pharyngitis Nos
Acute Pharyngeal Inflammation	Inflammation Of The Throat
Throat Inflammation	Throat Infection
Putrid Pharyngitis	Pharyngeal Inflammation
Pharyngitis Nos	Chronic Throat Pain
Throat Catarrh

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13699	SPON2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPON2	MGD	MGI:1923724
Bos taurus	SPON2	VGNC	VGNC:35228
Macaca mulatta	SPON2	VGNC	VGNC:82245
Felis catus	SPON2	VGNC	VGNC:80010
Canis familiaris	SPON2	VGNC	VGNC:59026
Rattus norvegicus	SPON2	RGD	RGD:708584
Others	SPON2	NCBI

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