PLEKHF2 - pleckstrin homology and FYVE domain containing 2 Gene

Homo sapiens

Also known as EAPF; PHAFIN2; ZFYVE18

Gene ID: 79666 | Gene type: protein coding

About PLEKHF2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:95,133,785-95,156,685 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 13 paralogues. Broad expression in bone marrow (RPKM 31.1), lymph node (RPKM 29.6) and 24 other tissues.

Summary

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in protein transport. Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHF2 Products(1)

mRNA	Protein	Name
NM_024613.4	NP_078889.1	pleckstrin homology domain-containing family F member 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHF2 Protein Structure

FYVE

0
100
200
249 a.a.

Protein Preferred Names

Protein Names

pleckstrin homology domain-containing family F member 2

PH and FYVE domain-containing protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10688	PLEKHF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLEKHF2	VGNC	VGNC:33013
Rattus norvegicus	PLEKHF2	RGD	RGD:1312029
Macaca mulatta	PLEKHF2	VGNC	VGNC:76084
Felis catus	PLEKHF2	VGNC	VGNC:64225
Mus musculus	PLEKHF2	MGD	MGI:1919051

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