2. Gene
  3. PLEKHF2 - pleckstrin homology and FYVE domain containing 2 Gene

PLEKHF2 - pleckstrin homology and FYVE domain containing 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EAPF; PHAFIN2; ZFYVE18

Gene ID: 79666 | Gene type: protein coding

About PLEKHF2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:95,133,785-95,156,685 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 13 paralogues. Broad expression in bone marrow (RPKM 31.1), lymph node (RPKM 29.6) and 24 other tissues.

Summary

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in protein transport. Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHF2 Products(1)

mRNA Protein Name
NM_024613.4 NP_078889.1 pleckstrin homology domain-containing family F member 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHF2 Protein Structure

PH

PH: PH domain (39 - 130)

FYVE

FYVE: FYVE zinc finger (148 - 211)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family F member 2

PH and FYVE domain-containing protein 2

PLEKHF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PLEKHF2 Q9H8W4 ZNF250 Homo sapiens P15622-3
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 ZNF250 Homo sapiens P15622-3
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 ZNF250 Homo sapiens P15622-3
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 MBIP Homo sapiens Q9NS73-5
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 MBIP Homo sapiens Q9NS73-5
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 TXNL4B Homo sapiens Q9NX01
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 BARHL2 Homo sapiens Q9NY43
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 SEC14L4 Homo sapiens Q9UDX3
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 PTPN3 Homo sapiens P26045
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 TNFAIP8 Homo sapiens O95379
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 TNFAIP8 Homo sapiens O95379
Y2H
21516116
Intra
PLEKHF2 Q9H8W4 TNFAIP8 Homo sapiens O95379
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 TNFAIP8 Homo sapiens O95379
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 RPRM Homo sapiens Q9NS64
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 RPRM Homo sapiens Q9NS64
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 FGF13 Homo sapiens Q92913
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 FGF13 Homo sapiens Q92913
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 GRAMD4 Homo sapiens Q6IC98
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 GRAMD4 Homo sapiens Q6IC98
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 ARID4B Homo sapiens Q4LE39-3
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 ARID4B Homo sapiens Q4LE39-3
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 KRTAP5-4 Homo sapiens Q6L8H1
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 KRTAP5-4 Homo sapiens Q6L8H1
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 RASGEF1B Homo sapiens Q0VAM2-3
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 RASGEF1B Homo sapiens Q0VAM2-3
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 SCYL1 Homo sapiens Q96KG9-4
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 SCYL1 Homo sapiens Q96KG9-4
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 SPATA24 Homo sapiens Q86W54-2
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 SPATA24 Homo sapiens Q86W54-2
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 MAGI2 Homo sapiens Q86UL8-2
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 MAGI2 Homo sapiens Q86UL8-2
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 NFIA Homo sapiens Q12857-2
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 NFIA Homo sapiens Q12857-2
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0-2
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0-2
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0-2
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 SPEF1 Homo sapiens Q9Y4P9-2
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 SPEF1 Homo sapiens Q9Y4P9-2
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 SPEF1 Homo sapiens Q9Y4P9-2
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 KCNJ5-AS1 Homo sapiens Q8TAV5
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 KCNJ5-AS1 Homo sapiens Q8TAV5
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 SNRNP35 Homo sapiens Q16560-2
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 SNRNP35 Homo sapiens Q16560-2
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 DOCK3 Homo sapiens Q8IZD9
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 DOCK3 Homo sapiens Q8IZD9
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 CHCHD2 Homo sapiens Q9Y6H1
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 GPBP1 Homo sapiens Q86WP2
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 L3MBTL3 Homo sapiens Q96JM7
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 L3MBTL3 Homo sapiens Q96JM7
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 CCDC25 Homo sapiens Q86WR0
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 CCDC25 Homo sapiens Q86WR0
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 NSD2 Homo sapiens O96028
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 NSD2 Homo sapiens O96028
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 YIF1A Homo sapiens O95070
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 EIF3C Homo sapiens Q99613
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 EIF3C Homo sapiens Q99613
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 XRN2 Homo sapiens Q9H0D6
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 XRN2 Homo sapiens Q9H0D6
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 RPE Homo sapiens Q96AT9
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 RPE Homo sapiens Q96AT9
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 ACY3 Homo sapiens Q96HD9
Y2H Array
31515488
Intra
PLEKHF2 Q9H8W4 ACY3 Homo sapiens Q96HD9
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 MEAF6 Homo sapiens Q9HAF1
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 DOCK2 Homo sapiens Q92608
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 DOCK2 Homo sapiens Q92608
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 BLOC1S6 Homo sapiens Q9UL45
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 PRKAR1A Homo sapiens P10644
Y2H Pooling
19060904
Intra
PLEKHF2 Q9H8W4 PRKAR1A Homo sapiens P10644
Y2H Array
19060904
Intra
PLEKHF2 Q9H8W4 FRMD8 Homo sapiens Q9BZ67
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 FRMD8 Homo sapiens Q9BZ67
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 EXOC7 Homo sapiens Q9UPT5-1
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 EXOC7 Homo sapiens Q9UPT5-1
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 EXOC7 Homo sapiens Q9UPT5-1
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 NPM2 Homo sapiens Q86SE8
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 NPM2 Homo sapiens Q86SE8
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 CRYBA1 Homo sapiens P05813
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 CRYBA1 Homo sapiens P05813
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 BRD7 Homo sapiens Q9NPI1
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 BRD7 Homo sapiens Q9NPI1
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 BRD7 Homo sapiens Q9NPI1
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 RPS21 Homo sapiens P63220
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 RPS21 Homo sapiens P63220
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 ADAP1 Homo sapiens O75689
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 ADAP1 Homo sapiens O75689
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 GFER Homo sapiens P55789
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 UBE2Z Homo sapiens Q9H832
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 UBE2Z Homo sapiens Q9H832
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 PACSIN1 Homo sapiens Q9BY11
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 PACSIN1 Homo sapiens Q9BY11
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 S100A13 Homo sapiens Q99584
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 S100A13 Homo sapiens Q99584
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 ZBTB6 Homo sapiens Q15916
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 ZBTB6 Homo sapiens Q15916
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 PPCDC Homo sapiens Q96CD2
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 PPCDC Homo sapiens Q96CD2
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 HSPB7 Homo sapiens Q9UBY9
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 FBXO28 Homo sapiens Q9NVF7
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 FBXO28 Homo sapiens Q9NVF7
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 FBXO28 Homo sapiens Q9NVF7
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 LDOC1 Homo sapiens O95751
Y2H Pooling
19060904
Intra
PLEKHF2 Q9H8W4 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 LDOC1 Homo sapiens O95751
Y2H Array
19060904
Intra
PLEKHF2 Q9H8W4 SEPTIN2 Homo sapiens Q15019
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 SEPTIN2 Homo sapiens Q15019
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 SEPTIN2 Homo sapiens Q15019
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 HEBP2 Homo sapiens Q9Y5Z4
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 HEBP2 Homo sapiens Q9Y5Z4
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 HEBP2 Homo sapiens Q9Y5Z4
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 MMTAG2 Homo sapiens Q9BU76
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 MMTAG2 Homo sapiens Q9BU76
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 TRAPPC3 Homo sapiens O43617
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 S100A1 Homo sapiens P23297
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 S100A1 Homo sapiens P23297
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 UGP2 Homo sapiens Q16851
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 UGP2 Homo sapiens Q16851
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 THAP10 Homo sapiens Q9P2Z0
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 ZNF581 Homo sapiens Q9P0T4
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 ZNF581 Homo sapiens Q9P0T4
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 NDUFA5 Homo sapiens Q16718
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 NDUFA5 Homo sapiens Q16718
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 THG1L Homo sapiens Q9NWX6
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 THG1L Homo sapiens Q9NWX6
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 THG1L Homo sapiens Q9NWX6
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 MRI1 Homo sapiens Q9BV20
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 MRI1 Homo sapiens Q9BV20
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 ZNF439 Homo sapiens Q8NDP4
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 ZNF439 Homo sapiens Q8NDP4
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 PAK1IP1 Homo sapiens Q9NWT1
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 YY1 Homo sapiens P25490
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 YY1 Homo sapiens P25490
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 INO80 Homo sapiens Q9ULG1
Validated Y2H
32296183
Intra
PLEKHF2 Q9H8W4 RSPO2 Homo sapiens Q6UXX9
Validated Y2H
25416956
Intra
PLEKHF2 Q9H8W4 ZNF398 Homo sapiens Q8TD17
Y2H Prey Pooling
25416956
Intra
PLEKHF2 Q9H8W4 ZNF398 Homo sapiens Q8TD17
Y2H Array
25416956
Intra
PLEKHF2 Q9H8W4 TRIM22 Homo sapiens Q8IYM9
Y2H Prey Pooling
32296183
Intra
PLEKHF2 Q9H8W4 TRIM22 Homo sapiens Q8IYM9
Y2H Array
32296183
Intra
PLEKHF2 Q9H8W4 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10688 PLEKHF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLEKHF2 VGNC VGNC:33013
Rattus norvegicus PLEKHF2 RGD RGD:1312029
Macaca mulatta PLEKHF2 VGNC VGNC:76084
Felis catus PLEKHF2 VGNC VGNC:64225
Mus musculus PLEKHF2 MGD MGI:1919051