RBM14 - RNA binding motif protein 14 Gene

Homo sapiens

Also known as SIP; COAA; PSP2; SYTIP1; TMEM137

Gene ID: 10432 | Gene type: protein coding

About RBM14

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,616,630-66,629,934 (from NCBI)

This gene has 9 transcripts (splice variants), 268 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 11.0), lymph node (RPKM 7.8) and 25 other tissues.

Summary

This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

RBM14 Products(3)

mRNA	Protein	Name
NM_001198836.2	NP_001185765.1	RNA-binding protein 14 isoform 2
NM_001198837.2	NP_001185766.1	RNA-binding protein 14 isoform 3
NM_006328.4	NP_006319.1	RNA-binding protein 14 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear receptor coactivator activity	IPI IPI: Inferred from physical interaction	11443112	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15919756	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in centriole assembly	IMP IMP: Inferred from mutant phenotype	25385835	GOA
involved in negative regulation of centriole replication	IMP IMP: Inferred from mutant phenotype	25385835	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11443112	GOA
involved in transcription initiation-coupled chromatin remodeling	IPI IPI: Inferred from physical interaction	11443112	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25385835	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25385835	GOA
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	11443112	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM14 Protein Structure

RRM_1

0
200
400
600
669 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein 14

RRM-containing coactivator activator/modulator

Recombinant RBM14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71612	RBM14 Protein, Human (His-SUMO)	Q96PK6 (M1-M669)	≥95%

Related Diseases

Diseases

Alias

Marginal Corneal Ulcer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150163	RBM14C12		/	Unkown
HY-RS11734	RBM14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RBM14	VGNC	VGNC:45408
Rattus norvegicus	RBM14	RGD	RGD:620542
Felis catus	RBM14	VGNC	VGNC:64520
Mus musculus	RBM14	MGD	MGI:1929092
Bos taurus	RBM14	VGNC	VGNC:56277
Others	RBM14	NCBI

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