2. Gene
  3. RBM14 - RNA binding motif protein 14 Gene

RBM14 - RNA binding motif protein 14 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SIP; COAA; PSP2; SYTIP1; TMEM137

Gene ID: 10432 | Gene type: protein coding

About RBM14

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,616,630-66,629,934 (from NCBI)

This gene has 9 transcripts (splice variants), 268 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 11.0), lymph node (RPKM 7.8) and 25 other tissues.

Summary

This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

RBM14 Products(3)

mRNA Protein Name
NM_001198836.2 NP_001185765.1 RNA-binding protein 14 isoform 2
NM_001198837.2 NP_001185766.1 RNA-binding protein 14 isoform 3
NM_006328.4 NP_006319.1 RNA-binding protein 14 isoform 1

RBM14 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (3 - 60)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (81 - 142)

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  • 669 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 14

RRM-containing coactivator activator/modulator

Recombinant RBM14 Proteins

Cat. No. Product Name Accession Purity
HY-P71612 RBM14 Protein, Human (His-SUMO) Q96PK6 (M1-M669) ≥95%

Related Diseases

Diseases Alias
Marginal Corneal Ulcer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150163 RBM14C12 / Unkown
HY-RS11734 RBM14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RBM14 VGNC VGNC:45408
Rattus norvegicus RBM14 RGD RGD:620542
Felis catus RBM14 VGNC VGNC:64520
Mus musculus RBM14 MGD MGI:1929092
Bos taurus RBM14 VGNC VGNC:56277
Others RBM14 NCBI