Pld4 - phospholipase D family, member 4 Gene

Mus musculus

Also known as thss

Gene ID: 104759 | Gene type: protein coding

About Pld4

Summary

Enables single-stranded DNA 5'-3' exodeoxyribonuclease activity. Involved in regulation of cytokine production involved in inflammatory response. Acts upstream of or within hematopoietic progenitor cell differentiation and phagocytosis. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum membrane; and trans-Golgi network membrane. Is expressed in brain and hemolymphoid system. Used to study systemic lupus erythematosus. Orthologous to human PLD4 (Phospholipase D family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Pld4 Products(1)

mRNA	Protein	Name
NM_178911.4	NP_849242.1	5'-3' exonuclease PLD4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables phospholipase D activity	IDA IDA: Inferred from direct assay	21085684	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18706977	MGI
enables single-stranded DNA 5'-3' DNA exonuclease activity	IMP IMP: Inferred from mutant phenotype	22102906	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	22102906	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24029230	MGI
acts upstream of or within phagocytosis	IMP IMP: Inferred from mutant phenotype	22102906	MGI
involved in regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	22102906	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	22102906	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21085684	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21085684	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22102906	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	22102906	MGI
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	21085684	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

5'-3' exonuclease PLD4

PLD 4	choline phosphatase 4
phosphatidylcholine-hydrolyzing phospholipase D4	phospholipase D4

Recombinant Pld4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77821	PLD4 Protein, Mouse (HEK293, His)	Q8BG07-1 (Q58-W503)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10673	PLD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pld4	NCBI	NCBI:122618

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