PROCR - protein C receptor Gene

Homo sapiens

Also known as CCCA; EPCR; CCD41

Gene ID: 10544 | Gene type: protein coding

About PROCR

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,171,096-35,216,259 (from NCBI)

This gene has 3 transcripts (splice variants), 119 orthologues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 14.7), fat (RPKM 10.7) and 24 other tissues.

Summary

The protein encoded by this gene is a receptor for activated protein C, a serine Protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial Infection and has been associated with Cancer. [provided by RefSeq, Jul 2013]

PROCR Products(1)

mRNA	Protein	Name
NM_006404.5	NP_006395.2	endothelial protein C receptor precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17299037	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of coagulation	IMP IMP: Inferred from mutant phenotype	19696402	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROCR Protein Structure

MHC_I

0
100
200
238 a.a.

Protein Preferred Names

Protein Names

endothelial protein C receptor

APC receptor

Recombinant PROCR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70936	EPCR Protein, Human (HEK293, His)	Q9UNN8 (S18-S210)	≥95%
HY-P75247	EPCR Protein, Human (HEK293, hFc)	Q9UNN8 (S18-T209)	≥95%

Related Diseases

Diseases

Alias

Purpura Fulminans

Purpura Gangrenosa

Thrombophilia

Hypercoagulability State

Thrombosis

Thrombosis Of Blood Vessel

Antiphospholipid Syndrome

Antiphospholipid Antibody Syndrome	Hughes Syndrome
Familial Antiphospholipid Syndrome	Aps
Lupus Anticoagulant, Familial	Anti-Phospholipid Syndrome
Apls	Classic Apls
Classic Antiphospholipid Syndrome	Acromegaloid Facial Appearance Syndrome
Anticardiolipin Syndrome

Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency	Proc Deficiency
Congenital Thrombotic Disease, Due To Protein C Deficiency

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Meningococcemia

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Disseminated Intravascular Coagulation

Defibrination Syndrome	Dic
Diffuse Or Disseminated Intravascular Coagulation	Fibrinolytic Purpura
Consumption Coagulopathy	Diffuse Intravascular Coagulation
Dic - [Disseminated Intravascular Coagulation]	Disseminated Intravascular Coagulopathy
Fibrinolysis Nos	Thrombolytic Purpura

Melioidosis

Melioidosis, Susceptibility To	Acute And Fulminating Melioidosis
Nightcliff Gardener'S Disease	Pseudoglanders
Subacute And Chronic Melioidosis	Burkholderia Pseudomallei Infection
Whitmore Disease	Whitmore'S Disease
B Pseudomallei Infection	Epizootic Lymphangitis
Infection Due To Burkholderia Pseudomallei	Infection Due To Burkholderia Pseudomallei Nos
Infection Due To Malleomyces Pseudomallei	Infection Due To Pseudomonas Pseudomallei
Infection Due To Pseudomonas Pseudomallei Nos	Infection Due To Whitmore Bacillus
Stanton Disease

Beta-Thalassemia

Beta Thalassemia	Cooley'S Anemia
Mediterranean Anemia	Beta Thalassemia Intermedia
Erythroblastic Anemia	Thalassemia, Hispanic Gamma-Delta-Beta
Thalassemia Major	Thalassemia Minor
Beta-Plus-Thalassemia	Thalassemia, Beta
Beta Thalassemia Major	Beta Thalassemia Minor
Thalassemias, Beta-	Microcytemia, Beta Type
Thalassemia, Beta Type	B-THAL
Mediterranean Anaemia	Beta Thalassaemia Syndrome
Mediterranean Disease	Beta Thalassaemia Disease

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Parasitic Protozoa Infectious Disease

Protozoan Infections	Mastigophora Infectious Disease
Sarcomastigophora Infectious Disease

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11191	PROCR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PROCR	VGNC	VGNC:69078
Mus musculus	PROCR	MGD	MGI:104596
Rattus norvegicus	PROCR	RGD	RGD:1305991
Canis familiaris	PROCR	VGNC	VGNC:45008
Bos taurus	PROCR	VGNC	VGNC:33359
Macaca mulatta	PROCR	VGNC	VGNC:107919
Macaca fascicularis	PROCR	NCBI	NCBI:102135397
Others	PROCR	NCBI

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