AGPAT1 - 1-acylglycerol-3-phosphate O-acyltransferase 1 Gene

Homo sapiens

Also known as G15; LPAATA; LPLAT1; 1-AGPAT1; LPAAT-alpha

Gene ID: 10554 | Gene type: protein coding

About AGPAT1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,168,212-32,178,108 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 139 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 25.5), brain (RPKM 21.6) and 25 other tissues.

Summary

This gene encodes an Enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two Phospholipids involved in signal transduction and in lipid biosynthesis in cells. This Enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

AGPAT1 Products(5)

mRNA	Protein	Name
NM_001371437.1	NP_001358366.1	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 2
NM_001371438.1	NP_001358367.1	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_001371439.1	NP_001358368.1	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_006411.4	NP_006402.1	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_032741.5	NP_116130.2	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	9461603	GOA
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IGI IGI: Inferred from genetic interaction	9212163	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phosphatidic acid biosynthetic process	IGI IGI: Inferred from genetic interaction	9212163	GOA
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	9212163	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	9461603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGPAT1 Protein Structure

Acyltransferase

0
100
200
283 a.a.

Protein Preferred Names

Protein Names

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1-AGP acyltransferase 1

AGPAT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AGPAT1	Q99943	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	AGPAT1	Q99943	RNASEH2A	Homo sapiens	O75792	Anti Tag CoIP	33961781
Intra	AGPAT1	Q99943	RNASEH2A	Homo sapiens	O75792	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lipodystrophy, Congenital Generalized, Type 1

Congenital Generalized Lipodystrophy Type 1	Bscl1
CGL1	Berardinelli-Seip Congenital Lipodystrophy, Type 1
Brunzell Syndrome Agpat2-Related	Berardinelli-Seip Congenital Lipodystrophy Type 1
Lipodystrophy, Berardinelli-Seip Congenital, Type 1	Brunzell Syndrome, Agpat2-Related
Agpat2-Related Brunzell Syndrome	Congenital Generalized Lipodystrophy 1
Berardinelli-Seip Syndrome	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Total Lipodystrophy And Acromegaloid Gigantism
Lipodystrophy, Generalized, Congenital, Type 1	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Complete Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2	CGL2
Berardinelli-Seip Congenital Lipodystrophy Type 2	Berardinelli-Seip Syndrome
Brunzell Syndrome Bscl2-Related	Total Lipodystrophy And Acromegaloid Gigantism
Berardinelli-Seip Congenital Lipodystrophy, Type 2	Seip Syndrome
Berardinelli Syndrome	Lipodystrophy, Total, And Acromegaloid Gigantism
Lipoatrophic Diabetes, Congenital	Lipodystrophy, Berardinelli-Seip Congenital, Type 2
Brunzell Syndrome, Bscl2-Related	Congenital Lipoatrophic Diabetes
Congenital Generalized Lipodystrophy 2	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence	Fads
Fetal Akinesia Sequence	FADS1
Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia	Pena-Shokeir Syndrome Type 1
Fetal Akinesia Deformation Sequence Syndrome	Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome
Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia	Pena-Shokeir Syndrome, Type I
Foetal Akinesia Deformation Sequence Syndrome	Foetal Akinesia Sequence
Fetal Akinesia Deformation Sequence Syndrome 1	Pena-Shokeir Syndrome, Type 1
Pena Shokeir Syndrome, Type 1	Akinesia, Fetal, Deformation Sequence
Akinesia, Fetal, Deformation Sequence, Type 1	Pena-Shokeir Syndrome Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00456	AGPAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AGPAT1	VGNC	VGNC:25734
Mus musculus	AGPAT1	MGD	MGI:1932075
Canis familiaris	AGPAT1	VGNC	VGNC:37710
Felis catus	AGPAT1	VGNC	VGNC:102377
Macaca mulatta	AGPAT1	VGNC	VGNC:69745
Rattus norvegicus	AGPAT1	RGD	RGD:1303287

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