CXCL13 - C-X-C motif chemokine ligand 13 Gene

Homo sapiens

Also known as BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13

Gene ID: 10563 | Gene type: protein coding

About CXCL13

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:77,511,753-77,611,834 (from NCBI)

This gene has 3 transcripts (splice variants), 118 orthologues and 12 paralogues. Biased expression in lymph node (RPKM 245.2), spleen (RPKM 177.4) and 3 other tissues.

Summary

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

CXCL13 Products(2)

mRNA	Protein	Name
NM_001371558.1	NP_001358487.1	C-X-C motif chemokine 13 precursor
NM_006419.3	NP_006410.1	C-X-C motif chemokine 13 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CCR10 chemokine receptor binding	IDA IDA: Inferred from direct assay	10706668	GOA
enables CXCR3 chemokine receptor binding	IPI IPI: Inferred from physical interaction	11554781	GOA
enables CXCR5 chemokine receptor binding	IDA IDA: Inferred from direct assay	9463416	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	11554781	GOA
enables fibroblast growth factor binding	IDA IDA: Inferred from direct assay	11708770	GOA
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	11708770	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	11708770	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	11554781	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell chemotaxis	IDA IDA: Inferred from direct assay	9463416	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	11554781	GOA
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	11554781	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	17562761	GOA
involved in endothelial cell chemotaxis to fibroblast growth factor	IDA IDA: Inferred from direct assay	11708770	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in negative regulation of endothelial cell chemotaxis to fibroblast growth factor	IDA IDA: Inferred from direct assay	11708770	GOA
involved in positive regulation of T cell chemotaxis	IDA IDA: Inferred from direct assay	11554781	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	11554781	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	17562761	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL13 Protein Structure

IL8

0
100
109 a.a.

Protein Preferred Names

Protein Names

C-X-C motif chemokine 13

B-cell chemoattractant

Recombinant CXCL13 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7131	BCA-1/CXCL13 Protein, Human	O43927 (V23-P109)	≥95%
HY-P700044AF	Animal-Free BCA-1/CXCL13 Protein, Human (His)	O43927 (V23-R94)	≥95%

Related Diseases

Diseases

Alias

Angioimmunoblastic T-Cell Lymphoma

Immunoblastic Lymphadenopathy	Lymphogranulomatosis X
T-Cell Lymphoma, Aild Type	Aitl
Ailt	Angioimmunoblastic Lymphadenopathy
Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia]	Angioimmunoblastic Lymphoma

Neurosyphilis

Syphilis Of Central Nervous System	Late Syphilis Of Central Nervous System Nos
Late Syphilis Of The Central Nervous System	Gumma Of Central Nervous System
Neurosyphilis Gumma	Neurosyphilitic Gumma
Syphilis Of Central Nervous System Nos	Syphilitic Gumma Of Central Nervous System
Tertiary Central Nervous System Syphilis

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Primary Central Nervous System Lymphoma

Pcnsl	Primary Cns Lymphoma
Primary Brain Lymphoma	Primary Lymphoma, Cns
Primary Cerebral Lymphoma

Asymptomatic Neurosyphilis

Neurosyphilis

Neurosyphilis, Asymptomatic

Tabes Dorsalis

Posterior Spinal Sclerosis	Tabes Dorsalis - Neurosyphilis
Syphilitic Myelopathy

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Meningovascular Neurosyphilis

Tertiary Neurosyphilis

Late Neurosyphilis

Late Syphilis Of Central Nervous System Nos

Neuromyelitis Optica

Devic Disease	Devic Syndrome
Neuromyelitis Optica Spectrum Disorder	Devic'S Disease
Devic'S Syndrome	Devic'S Neuromyelitis Optica
Nmo	Nmo Spectrum Disorder
Neuromyelitis Optica Spectrum Disorders	Devic Neuromyelitis Optica
Optic-Spinal Ms	Opticospinal Ms
Nmosd	Opticospinal Multiple Sclerosis
Devic	Ophthalmoneuromyelitis
Optic Neuromyelitis	Optic Neuroencephalomyelopathy
Nmo - [Neuromyelitis Optica]	Optic Neuritis With Demyelination

Endometritis

Castleman Disease

Angiofollicular Ganglionic Hyperplasia	Angiofollicular Lymph Hyperplasia
Giant Lymph Node Hyperplasia	Castleman'S Disease
Angiofollicular Lymph Node Hyperplasia	Lymphoid Hamartoma
Benign Giant Lymphoma	Angiolymphoid Hyperplasia

Syphilitic Meningitis

Syphilitic Aseptic Meningitis	Meningeal Syphilis
Meningitis, Syphilitic

Tertiary Syphilis

Late Syphilis	Syphilis, Tertiary
Late Syphilis, Unspecified	Late Tertiary Syphilis

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Optic Neuritis

Inflammatory Optic Neuropathy

Sjogren Syndrome

Sicca Syndrome	Sjogren'S Syndrome
Sjögren Syndrome	Sjogren-Gougerot Syndrome
Keratoconjunctivitis Sicca	Sjögren'S Syndrome
Xerodermosteosis	Dacryosialoadenopathia Atrophicans
Gougerot-Houwer-Sjogren Syndrome	Gougerot-Sjogren Syndrome
Keratoconjunctivitis Sicca-Xerostomia	Secreto-Inhibitor-Xerodermostenosis
Primary Sjogren Syndrome	Primary Sjogren-Gougerot Syndrome
Sjogrens Syndrome Primary	Sjogrens Syndrome
Dry Eye Syndromes

Cryoglobulinemia

Cryoimmunoglobulinaemia

B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma	B-All
Precursor B Lymphoblastic Lymphoma/Leukemia	C-All
Lymphoblastic Lymphoma, Nos	Common Precursor B All
Lymphoblastic B-Cell Lymphoma	Pro-B All
B-Precursor Lymphoma	Lbl - [Lymphoblastic Lymphoma]

Eye Lymphoma

Malignant Lymphoma Of Eye

Lymphoma Of Eye

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Meningitis

Streptococcal Meningitis	Acute Streptococcal Meningitis
Staphylococcal Meningitis	Adenoviral Meningitis
Influenza Meningitis	Influenzal Meningitis
Meningitis Due To H. Influenzae	Cryptococcal Meningitis
Fungal Meningitis Due To Cryptococcus Neoformans	Cryptococcosis Meningitis
Cryptococcus Meningitis	Cryptococcal Meningoencephalitis
Meningitis Due To Cryptococcus	Mumps Virus Meningitis
Mumps Meningitis

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Intraocular Lymphoma

Primary Intraocular Lymphoma	Piol
Primary Intraocular Non-Hodgkin Lymphoma	Primary Intraocular Non-Hodgkin Malignant Lymphoma

Latent Syphilis

Syphilis, Latent

Acrodermatitis Chronica Atrophicans

Acrodermatitis Atrophicans Chronica	Herxheimer Disease
Primary Diffuse Atrophy

Secondary Syphilis

Syphilis, Secondary

Secondary Syphilis Of Viscera Or Bone

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Autoimmune Disease Of Exocrine System

Central Nervous System Lymphoma

Microglioma	Primary Cns Lymphoma
Cns Lymphoma	Primary Central Nervous System Lymphoma

Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor	Hematopoietic Neoplasm Of Central Nervous System
Central Nervous System Hematopoietic Neoplasm

Viral Meningitis

Meningitis Viral	Meningitis, Viral
Viral Meningitis Nec

Polyclonal Hypergammaglobulinemia

Polyclonal Gammopathy

Primary Progressive Multiple Sclerosis

Ppms	Primary-Progressive Ms
Multiple Sclerosis, Primary Progressive

Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma

Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis	Encephalitis, Tick-Borne
Central European Encephalitis	Far Eastern Tbe
Russian Spring-Summer Encephalitis	Taiga Encephalitis
West-Siberian Encephalitis	Western European Tick-Borne Encephalitis
Tbe	Encephalitis Tick-Borne
Encephalitis, Central European	Encephalitis, Far Eastern Russian

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Sodoku Disease

Spirillosis	Sodoku
Spirillary Fever	Rat-Bite Fever
Rat-Bite Fever Due To Spirillum Minus	Spirillary Rat-Bite Fever
Sokosho

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03387	CXCL13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CXCL13	VGNC	VGNC:71393
Canis familiaris	CXCL13	VGNC	VGNC:39747
Rattus norvegicus	CXCL13	RGD	RGD:1564256
Mus musculus	CXCL13	MGD	MGI:1888499
Felis catus	CXCL13	VGNC	VGNC:78478
Bos taurus	CXCL13	VGNC	VGNC:27849
Macaca fascicularis	CXCL13	NCBI	NCBI:102123271
Susscrofa domestica	CXCL13	NCBI
Others	CXCL13	NCBI