GNLY - granulysin Gene

Homo sapiens

Also known as LAG2; NKG5; LAG-2; D2S69E; TLA519

Gene ID: 10578 | Gene type: protein coding

About GNLY

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,694,358-85,698,852 (from NCBI)

This gene has 14 transcripts (splice variants) and 50 orthologues. Biased expression in bone marrow (RPKM 67.6), endometrium (RPKM 42.4) and 5 other tissues.

Summary

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GNLY Products(3)

mRNA	Protein	Name
NM_001302758.2	NP_001289687.1	granulysin isoform 1 precursor
NM_006433.5	NP_006424.2	granulysin isoform 2 precursor
NM_012483.4	NP_036615.2	granulysin isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	9756476	GOA
involved in cellular defense response	IDA IDA: Inferred from direct assay	9756476	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	9756476	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	9756476	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with cytolytic granule	IDA IDA: Inferred from direct assay	9756476	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNLY Protein Structure

SapB_2

0
100
145 a.a.

Protein Preferred Names

Protein Names

granulysin

T-cell activation protein 519

Related Diseases

Diseases

Alias

Erythema Multiforme

Dermatostomatitis, Erythema Multiforme Type	Em
Erythema Multiforme Bullosum	Erythema Polymorphe, Erythema Multiforme Type
Febrile Mucocutaneous Syndrome	Herpes Iris, Erythema Multiforme Type
Stevens-Johnson Syndrome	Em - [Erythema Multiforme]

Kyphoscoliotic Heart Disease

Folliculitis

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis

Severe Cutaneous Adverse Reaction

Stevens-Johnson Syndrome	Toxic Epidermal Necrolysis
Drug-Induced Stevens Johnson Syndrome	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Susceptibility To Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Lyell'S Syndrome	Lyell Syndrome
Severe Cutaneous Adverse Reaction, Susceptibility To	Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To
Hypersensitivity Syndrome, Carbamazepine-Induced	Stevens-Johnson Syndrome, Susceptibility To
Toxic Epidermal Necrolysis, Susceptibility To	Sjs/Ten
Susceptibility To Severe Cutaneous Adverse Reaction Ity To	Mycoplasma-Induced Stevens Johnson Syndrome
Dermatostomatitis, Stevens Johnson Type	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Sjs-Ten	Toxic Epidermolysis
SJS	Dermatostomatitis Stevens Johnson Type
Ten	Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis]
Ten - [Toxic Epidermal Necrolysis]

Phenytoin Allergy

Dilantin Allergy

Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

Cadasil	Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Casil	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Familial Vascular Leukoencephalopathy	CADASIL1
Cadasil 1	Hereditary Multi-Infarct Dementia
Cadasil Syndrome	Dementia, Hereditary Multiinfarct Type
Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1	Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy	Dementia, Hereditary Multi-Infarct Type
Hereditary Dementia, Multi-Infarct Type	Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant
Dementia Hereditary Multiinfarct Type	Dementia Hereditary Multi-Infarct Type
Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy

Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy

Spondylocostal Dysostosis

Jarcho-Levin Syndrome	Costovertebral Dysplasia
Spondylothoracic Dysostosis	Spondylothoracic Dysplasia
Scdo	Dysostosis, Spondylocostal

Tick Paralysis

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110266	GN44028	Inhibitor	99.48%	Unkown
HY-117280	GN25	Activator	98.81%	Unkown
HY-163338	Metallo-β-lactamase-IN-13	Inhibitor	/	Unkown
HY-163339	Metallo-β-lactamase-IN-14	Inhibitor	/	Unkown
HY-RS05568	GNLY Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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