IGF2BP3 - insulin like growth factor 2 mRNA binding protein 3 Gene

Homo sapiens

Also known as KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3

Gene ID: 10643 | Gene type: protein coding

About IGF2BP3

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:23,310,209-23,470,491 (from NCBI)

This gene has 18 transcripts (splice variants), 224 orthologues and 12 paralogues. Biased expression in placenta (RPKM 12.9), testis (RPKM 2.5) and 2 other tissues.

Summary

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

IGF2BP3 Products(1)

mRNA	Protein	Name
NM_006547.3	NP_006538.2	insulin-like growth factor 2 mRNA-binding protein 3

IGF2BP3 Protein Structure

RRM_1

KH_1

0
100
200
300
400
500
579 a.a.

Protein Preferred Names

Protein Names

insulin-like growth factor 2 mRNA-binding protein 3

IGF-II mRNA-binding protein 3

Related Diseases

Diseases

Alias

Langerhans Cell Sarcoma

Malignant Langerhans Cell Sarcoma

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Barrett Esophagus

Barrett'S Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia	Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis	Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus	Barretts Syndrome
Barrett Syndrome	BE
Peptic Ulcer Of Esophagus	Adenocarcinoma Of Esophagus

Pilomyxoid Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06621	IGF2BP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IGF2BP3	VGNC	VGNC:30081
Rattus norvegicus	IGF2BP3	RGD	RGD:1306512
Canis familiaris	IGF2BP3	VGNC	VGNC:41900
Macaca mulatta	IGF2BP3	VGNC	VGNC:73453
Felis catus	IGF2BP3	VGNC	VGNC:62890
Mus musculus	IGF2BP3	MGD	MGI:1890359
Others	IGF2BP3	NCBI

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