FUT9 - fucosyltransferase 9 Gene

Homo sapiens

Also known as Fuc-TIX

Gene ID: 10690 | Gene type: protein coding

About FUT9

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:96,015,974-96,215,612 (from NCBI)

This gene has 2 transcripts (splice variants), 480 orthologues and 7 paralogues. Biased expression in brain (RPKM 9.0), stomach (RPKM 7.9) and 2 other tissues.

Summary

The protein encoded by this gene belongs to the Glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor Polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria Infection. [provided by RefSeq, Nov 2011]

FUT9 Products(1)

mRNA	Protein	Name
NM_006581.4	NP_006572.2	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA IDA: Inferred from direct assay	11278338	GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IMP IMP: Inferred from mutant phenotype	10622713	GOA
enables alpha-(1->3)-fucosyltransferase activity	IDA IDA: Inferred from direct assay	37202521	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	37202521	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Lewis x epitope biosynthetic process	IDA IDA: Inferred from direct assay	29593094	GOA
involved in fucosylation	IDA IDA: Inferred from direct assay	18395013	GOA
involved in glycosphingolipid biosynthetic process	IDA IDA: Inferred from direct assay	29593094	GOA
involved in neuron differentiation	IDA IDA: Inferred from direct assay	17335083	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23000574	GOA
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA
involved in regulation of leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	23192350	GOA
involved in regulation of leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	23192350	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in trans-Golgi network	IDA IDA: Inferred from direct assay	23192350	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	18395013	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT9 Protein Structure

Glyco_transf_10

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

alpha-(1,3)-fucosyltransferase 9

FUT9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FUT9	Q9Y231	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	FUT9	Q9Y231	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	FUT9	Q9Y231	FKBP14	Homo sapiens	Q9NWM8	Anti Tag CoIP	33961781
Intra	FUT9	Q9Y231	FKBP14	Homo sapiens	Q9NWM8	Anti Tag CoIP	28514442
Intra	FUT9	Q9Y231	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	FUT9	Q9Y231	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	FUT9	Q9Y231	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	FUT9	Q9Y231	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 46

MRD46	Mental Retardation, Autosomal Dominant 46
Autosomal Dominant Mental Retardation 46	Autosomal Dominant Intellectual Developmental Disorder 46
Mental Retardation, Autosomal Dominant, Type 46

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Walker-Warburg Syndrome

Hard Syndrome	Walker-Warburg Congenital Muscular Dystrophy
Cerebroocular Dysplasia-Muscular Dystrophy Syndrome	Cod-Md Syndrome
Chemke Syndrome	Hydrocephalus, Agyria And Retinal Dysplasia
Cerebroocular Dysgenesis	Cerebroocular Dysplasia Muscular Dystrophy Syndrome
Hard +/- E Syndrome	Pagon Syndrome
Warburg Syndrome	Hydrocephalus, Agyria, And Retinal Dysplasia
Mddga	Muscular Dystrophy-Dystroglycanopathy , Type A
Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A	Hydrocephalus-Agyria-Retinal Dysplasia Syndrome
Wws	Dystrophy, Muscular, Dystroglycanopathy, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70158	Fucosyltransferase 9		/	Unkown
HY-RS05160	FUT9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FUT9	VGNC	VGNC:72830
Felis catus	FUT9	VGNC	VGNC:62395
Mus musculus	FUT9	MGD	MGI:1330859
Bos taurus	FUT9	VGNC	VGNC:29153
Rattus norvegicus	FUT9	RGD	RGD:619955
Canis familiaris	FUT9	VGNC	VGNC:41016

Name
Email *

	Sorry, but the email address you supplied was invalid.