PLK2 - polo like kinase 2 Gene

Homo sapiens

Also known as SNK; hSNK; hPlk2

Gene ID: 10769 | Gene type: protein coding

About PLK2

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:58,453,982-58,460,086 (from NCBI)

This gene has 15 transcripts (splice variants), 221 orthologues and 4 paralogues. Broad expression in spleen (RPKM 41.3), placenta (RPKM 28.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

PLK2 Products(2)

mRNA	Protein	Name
NM_001252226.2	NP_001239155.1	serine/threonine-protein kinase PLK2 isoform 2
NM_006622.4	NP_006613.2	serine/threonine-protein kinase PLK2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent protein binding	IDA IDA: Inferred from direct assay	23983262	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20352051	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19001868	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15242618	GOA
involved in mitotic spindle organization	IDA IDA: Inferred from direct assay	19001868	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	23983262	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	23983262	GOA
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	23983262	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	20352051	GOA
involved in regulation of centriole replication	IDA IDA: Inferred from direct assay	19001868	GOA
involved in regulation of centriole replication	IMP IMP: Inferred from mutant phenotype	15242618	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriole	IDA IDA: Inferred from direct assay	19001868	GOA
located in centrosome	IDA IDA: Inferred from direct assay	15242618	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23983262	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLK2 Protein Structure

Pkinase

POLO_box

0
200
400
600
685 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PLK2

PLK-2	serine/threonine-protein kinase SNK
serum-inducible kinase

PLK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLK2	Q9NYY3	CENPJ	Homo sapiens	Q9HC77	Protein Kinase Assay	20531387

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Epilepsy, Familial Temporal Lobe, 2

Familial Temporal Lobe Epilepsy 2	Temporal Epilepsy, Familial
ETL2	Ftle
Epilepsy, Familial Temporal Lobe	Familial Temporal Lobe Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12137	Volasertib	Inhibitor	99.41%	Yes
HY-12137A	Volasertib trihydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12037A	Rigosertib	Inhibitor	99.01%	Phase 3
HY-12037	Rigosertib sodium	Inhibitor	99.57%	Phase 3
HY-50698	BI 2536	Inhibitor	99.95%	Phase 2
HY-147298	Plogosertib	Inhibitor	99.95%	Phase 2
HY-15160	TAK-960	Inhibitor	99.75%	Phase 1
HY-15160B	TAK-960 dihydrochloride	Inhibitor	99.19%	Phase 1
HY-15160A	TAK-960 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100789	ON1231320	Inhibitor	99.24%	Unkown
HY-108597	TC-S 7005	Inhibitor	99.68%	Unkown
HY-12134	Poloxin	Inhibitor	98.01%	Unkown
HY-115589	YLT-11	Inhibitor	/	Unkown
HY-149100	PLK1-IN-6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLK2	RGD	RGD:620760
Macaca mulatta	PLK2	VGNC	VGNC:76076
Canis familiaris	PLK2	VGNC	VGNC:44696
Mus musculus	PLK2	MGD	MGI:1099790
Bos taurus	PLK2	VGNC	VGNC:33034
Felis catus	PLK2	VGNC	VGNC:64244

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