2. Gene
  3. PLK2 - polo like kinase 2 Gene

PLK2 - polo like kinase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SNK; hSNK; hPlk2

Gene ID: 10769 | Gene type: protein coding

About PLK2

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:58,453,982-58,460,086 (from NCBI)

This gene has 15 transcripts (splice variants), 221 orthologues and 4 paralogues. Broad expression in spleen (RPKM 41.3), placenta (RPKM 28.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

PLK2 Products(2)

mRNA Protein Name
NM_001252226.2 NP_001239155.1 serine/threonine-protein kinase PLK2 isoform 2
NM_006622.4 NP_006613.2 serine/threonine-protein kinase PLK2 isoform 1

PLK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (83 - 334)

POLO_box

POLO_box: POLO box duplicated region (510 - 573)

POLO_box

POLO_box: POLO box duplicated region (607 - 676)

  • 0
  • 200
  • 400
  • 600
  • 685 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK2

PLK-2

serine/threonine-protein kinase SNK

serum-inducible kinase

Related Diseases

Diseases Alias
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Epilepsy, Familial Temporal Lobe, 2

Familial Temporal Lobe Epilepsy 2

Temporal Epilepsy, Familial

ETL2

Ftle

Epilepsy, Familial Temporal Lobe

Familial Temporal Lobe Epilepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137 Volasertib Inhibitor 99.41% Yes
HY-12137A Volasertib trihydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12037A Rigosertib Inhibitor 98.35% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100789 ON1231320 Inhibitor 99.24% Unkown
HY-108597 TC-S 7005 Inhibitor 99.56% Unkown
HY-12134 Poloxin Inhibitor 98.01% Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLK2 RGD RGD:620760
Macaca mulatta PLK2 VGNC VGNC:76076
Canis familiaris PLK2 VGNC VGNC:44696
Mus musculus PLK2 MGD MGI:1099790
Bos taurus PLK2 VGNC VGNC:33034
Felis catus PLK2 VGNC VGNC:64244